儿童哮喘是慢性阻塞性肺疾病发生的一个风险因素。
Childhood asthma is a risk factor for the development of chronic obstructive pulmonary disease.
作者信息
McGeachie Michael J
机构信息
Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
出版信息
Curr Opin Allergy Clin Immunol. 2017 Apr;17(2):104-109. doi: 10.1097/ACI.0000000000000348.
Abstract
PURPOSE OF REVIEW
This review will catalog the many recent longitudinal studies that have investigated the relationship between asthma and lung function, or the persistence and trajectories of lung function deficits.
RECENT FINDINGS
Recent work has reported on 50-year follow-ups of some prominent population cohorts. A history of asthma confers a 10-30-fold risk of chronic obstructive pulmonary disease. Individuals reaching a reduced maximum growth of forced expiratory volume in 1 s in early adulthood are at risk for early or more severe chronic obstructive pulmonary disease (COPD).
SUMMARY
Taken together, there is a wealth of overlapping cohort studies of lung function, asthma and COPD. These show that asthma is associated with reduced lung function, which may start in infancy or prenatally, persists through childhood and adulthood and predisposes for early or more severe COPD.
摘要
综述目的
本综述将梳理近期多项纵向研究，这些研究调查了哮喘与肺功能之间的关系，或肺功能缺陷的持续性及发展轨迹。
近期研究发现
近期有研究报道了对一些著名人群队列的50年随访情况。哮喘病史使患慢性阻塞性肺疾病的风险增加10至30倍。在成年早期1秒用力呼气量最大增长值降低的个体，有患早期或更严重慢性阻塞性肺疾病（COPD）的风险。
总结
综上所述，有大量关于肺功能、哮喘和慢性阻塞性肺疾病的重叠队列研究。这些研究表明，哮喘与肺功能降低有关，这种降低可能始于婴儿期或产前，贯穿儿童期和成年期，并易导致早期或更严重的慢性阻塞性肺疾病。
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