Peng Han, Park Jong Kook, Lavker Robert M
Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States.
Invest Ophthalmol Vis Sci. 2017 Jan 1;58(1):416-423. doi: 10.1167/iovs.16-21111.
Autophagy and macropinocytosis are processes that are vital for cellular homeostasis, and help cells respond to stress and take up large amounts of material, respectively. The limbal and corneal epithelia have the machinery necessary to carry out both processes; however, autophagy and macropinocytosis are relatively understudied in these two epithelia. In this Perspectives, we describe the basic principles behind macropinocytosis and autophagy, discuss how these two processes are regulated in the limbal and corneal epithelia, consider how these two processes impact on the physiology of limbal and corneal epithelia, and elaborate on areas of future research in autophagy and macropinocytosis as related to the limbal/corneal epithelia.
自噬和巨吞饮作用是对细胞稳态至关重要的过程，分别帮助细胞应对应激和摄取大量物质。角膜缘和角膜上皮具备执行这两个过程所需的机制；然而，这两种上皮中的自噬和巨吞饮作用相对较少受到研究。在本观点文章中，我们描述了巨吞饮作用和自噬背后的基本原理，讨论这两个过程在角膜缘和角膜上皮中是如何被调控的，思考这两个过程如何影响角膜缘和角膜上皮的生理学，并阐述与角膜缘/角膜上皮相关的自噬和巨吞饮作用未来的研究领域。
