核自噬：对既往观察的新视角
Nucleophagy: A New Look at Past Observations.
作者信息
Peng Han, Lavker Robert M
机构信息
Department of Dermatology, Northwestern University, Chicago, Illinois, USA.
Department of Dermatology, Northwestern University, Chicago, Illinois, USA.
出版信息
J Invest Dermatol. 2016 Jul;136(7):1316-1318. doi: 10.1016/j.jid.2016.04.019. Epub 2016 May 5.
Abstract
Keratinization of the stratum corneum involves a highly choreographed sequence of events in which granular cells lose their nuclei and become desiccated corneocytes. Akinduro et al. detail the molecular machinery underlying removal of the nucleus (nucleophagy) during the final stages of keratinization. They provide evidence that nucleophagy is induced when the keratinocytes differentiate and that failure in the initiation of nucleophagy is associated with parakeratosis.
摘要
角质层的角质化涉及一系列精心编排的事件，在此过程中，颗粒细胞失去细胞核并变成干燥的角质形成细胞。阿金杜罗等人详细阐述了角质化最后阶段细胞核清除（核自噬）背后的分子机制。他们提供的证据表明，角质形成细胞分化时会诱导核自噬，且核自噬起始失败与角化不全有关。
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