胃癌中爱泼斯坦-巴尔病毒的基因表达与潜伏模式：一项系统综述
Epstein-Barr virus gene expression and latency pattern in gastric carcinomas: a systematic review.
作者信息
Ribeiro Joana, Oliveira Cláudia, Malta Mariana, Sousa Hugo
机构信息
Molecular Oncology & Viral Pathology Group (CI-IPOP), Portuguese Oncology Institute of Porto (IPO-Porto), Rua Dr. António Bernardino Almeida, 4200-072 Porto, Portugal.
Virology Service, Portuguese Oncology Institute of Porto (IPO-Porto), Rua Dr. António Bernardino Almeida, 4200-072 Porto, Portugal.
出版信息
Future Oncol. 2017 Mar;13(6):567-579. doi: 10.2217/fon-2016-0475. Epub 2017 Jan 25.
METHODS
A systematic review of literature was conducted to identify all published reports regarding the expression of Epstein-Barr Virus (EBV) proteins/transcripts and EBV latency patterns in EBV-associated gastric carcinomas (EBVaGC).
RESULTS
The literature search retrieved 247 papers, of which 25 papers matched the inclusion criteria. The analysis reveals that the most frequently expressed EBV latent proteins are EBNA1 (98.1%) and LMP2A (53.8%), while LMP1 and LMP2B are present in only 10% of cases. Lytic proteins, such as BARF0 and BARF1, and other lytic transcripts are present in almost half of cases.
CONCLUSION
EBVaGC seems to display a unique transcription/latency pattern that does not fit the 'standard' EBV latency patterns and therefore should be further studied to better understand EBVaGC carcinogenesis.
方法
进行了一项文献系统综述，以识别所有已发表的关于爱泼斯坦-巴尔病毒（EBV）蛋白/转录本表达以及EBV相关胃癌（EBVaGC）中EBV潜伏模式的报告。
结果
文献检索获得了247篇论文，其中25篇符合纳入标准。分析显示，最常表达的EBV潜伏蛋白是EBNA1（98.1%）和LMP2A（53.8%），而LMP1和LMP2B仅在10%的病例中出现。裂解蛋白，如BARF0和BARF1，以及其他裂解转录本在近一半的病例中存在。
结论
EBVaGC似乎呈现出一种独特的转录/潜伏模式，不符合“标准”的EBV潜伏模式，因此应进一步研究以更好地理解EBVaGC的致癌机制。
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