Hashemi Zahra Sadat, Khalili Saeed, Forouzandeh Moghadam Mehdi, Sadroddiny Esmaeil
a Department of Medical Biotechnology, School of Advanced Technologies in Medicine , Tehran University of Medical Science , Tehran , Iran.
b Department of Clinical Laboratory Sciences , Dezful University of Medical Sciences , Dezful , Iran.
Expert Rev Respir Med. 2017 Feb;11(2):147-157. doi: 10.1080/17476348.2017.1279403.
Lung cancer still accounts for the leading cause of cancer-related deaths worldwide and despite the emerging advances in diagnostic and therapeutic techniques it remains to be a serious global public health concern. Micro-ribonucleic acids (microRNAs) are responsible for invasion and metastasis of various tumors including lung cancer which underscores the necessity of understanding their functions. Areas covered: Herein, we aim to summarize the recent advances made in our understanding of the miRNAs with special reference to lung cancer. Moreover, the role of miRNAs in crucial cellular processes will be elucidated. Various applications of the miRNAs would be explained and different kinds of them would be discussed to delineate their significance in lung cancer biology, therapy and diagnosis. Expert commentary: the miRNA study in the field of respiratory disease and specially lung cancer has emerged lately. Given the several miRNAs, which are in the clinical trials, this field is passing through its maturation phase which ultimately could rise to a robust tool for lung cancer therapy, diagnosis and prevention.
肺癌仍然是全球癌症相关死亡的主要原因，尽管诊断和治疗技术不断取得新进展，但它仍是一个严重的全球公共卫生问题。微小核糖核酸（microRNAs）与包括肺癌在内的各种肿瘤的侵袭和转移有关，这凸显了了解其功能的必要性。涵盖领域：在此，我们旨在总结我们对微小核糖核酸的最新认识进展，特别提及肺癌。此外，还将阐明微小核糖核酸在关键细胞过程中的作用。将解释微小核糖核酸的各种应用，并讨论不同类型的微小核糖核酸，以阐明它们在肺癌生物学、治疗和诊断中的意义。专家评论：呼吸疾病领域，特别是肺癌领域的微小核糖核酸研究最近才出现。鉴于有几种微小核糖核酸正在进行临床试验，该领域正处于成熟阶段，最终可能发展成为肺癌治疗、诊断和预防的有力工具。
