己内酰胺在哺乳动物斑点试验中可能的重组效应。

Possible recombinogenic effect of caprolactam in the mammalian spot test.

作者信息

Fahrig R

机构信息

Fraunhofer-Institut für Toxikologie und Aerosolforschung, Abteilung Genetik, F.R.G.

出版信息

Mutat Res. 1989 Nov;224(3):373-5. doi: 10.1016/0165-1218(89)90183-3.

DOI:10.1016/0165-1218(89)90183-3

PMID:2811929

Abstract

Tests of caprolactam in the mouse spot test showed that treatment with this compound increased the frequency of color spots among animals treated in utero. The nature of these spots suggests that caprolactam may induce spots through the induction of mitotic recombination.

摘要

在小鼠斑点试验中对己内酰胺进行的测试表明，用这种化合物处理会增加子宫内接受处理的动物身上色斑的出现频率。这些色斑的性质表明，己内酰胺可能通过诱导有丝分裂重组来诱发色斑。