Tonak J, Hermanek P, Groitl H
Aust N Z J Surg. 1978 Jun;48(3):282-6. doi: 10.1111/j.1445-2197.1978.tb05230.x.
In the prognosis of malignant melanoma the clinical stage and the microstage are the most important factors. According to the microstage, malignant melanomas can be divided into low-risk and high-risk melanomas. The subungual-volar melanoma seems to be an exception. Irrespective of the microstage, the prognosis of this type is probably worse than that of other types of melanoma. In patients with clinical Stage I the therapy should be individualized. In a low-risk melanoma, a wide local excision is sufficient; in a high-risk melanoma an additional regional lymph node dissection appears to be indicated; and if the primary tumour is located on an extremity a hyperthermic perfusion is also called for.
在恶性黑色素瘤的预后方面，临床分期和微观分期是最重要的因素。根据微观分期，恶性黑色素瘤可分为低风险和高风险黑色素瘤。甲下-掌跖部黑色素瘤似乎是个例外。无论微观分期如何，这种类型的预后可能比其他类型的黑色素瘤更差。对于临床I期患者，治疗应个体化。对于低风险黑色素瘤，广泛局部切除就足够了；对于高风险黑色素瘤，似乎需要额外进行区域淋巴结清扫；如果原发性肿瘤位于四肢，还需要进行热灌注治疗。
