Site-specific drug delivery to CNS: old and new.
作者信息
Hollister L E
机构信息
University of Texas Medical School, Houston.
出版信息
Neurobiol Aging. 1989 Sep-Oct;10(5):631; discussion 648-50. doi: 10.1016/0197-4580(89)90156-5.
PMID:2812240
Abstract
Delivery of drugs to specific sites in the CNS represents an essential therapeutic challenge. Extradural administration of opiates successfully delivers drugs to the CNS. The levodopa-carbidopa combination achieved some degree of site-specific delivery by pharmacological methods. Antibiotics have been administered through cannula directly into ventricles. Invasive methods offer the greatest degree of site-specificity.
摘要
Zotero 插件