Cidade M T, Ramos D J, Santos J, Carrelo H, Calero N, Borges J P
i3N/CENIMAT, Department of Materials Science, Faculty of Sciences and Technology, Universidade, NOVA de Lisboa, Campus de Caparica, 2829-516 Caparica, Portugal.
Applied Rheology, Colloid Technology, Chemical Engineering Department, University of Sevilla, c/ P. García González, 1, E41012 Sevilla, Spain.
Materials (Basel). 2019 Apr 2;12(7):1083. doi: 10.3390/ma12071083.
A (model) composite system for drug delivery was developed based on a thermoresponsive hydrogel loaded with microparticles. We used Pluronic F127 hydrogel as the continuous phase and alginate microparticles as the dispersed phase of this composite system. It is well known that Pluronic F127 forms a gel when added to water in an appropriate concentration and in a certain temperature range. Pluronic F127 hydrogel may be loaded with drug and injected, in its sol state, to act as a drug delivery system in physiological environment. A rheological characterization allowed the most appropriate concentration of Pluronic F127 (15.5 wt%) and appropriate alginate microparticles contents (5 and 10 wt%) to be determined. Methylene blue (MB) was used as model drug to perform drug release studies in MB loaded Pluronic hydrogel and in MB loaded alginate microparticles/Pluronic hydrogel composite system. The latter showed a significantly slower MB release than the former (10 times), suggesting its potential in the development of dual cargo release systems either for drug delivery or tissue engineering.
基于负载微粒的热响应水凝胶开发了一种（模型）复合药物递送系统。我们使用泊洛沙姆F127水凝胶作为该复合系统的连续相，藻酸盐微粒作为分散相。众所周知，泊洛沙姆F127在适当浓度和一定温度范围内加入水中时会形成凝胶。泊洛沙姆F127水凝胶可以负载药物并以其溶胶状态注射，以在生理环境中充当药物递送系统。流变学表征确定了最合适的泊洛沙姆F127浓度（15.5 wt%）和合适的藻酸盐微粒含量（5 wt%和10 wt%）。使用亚甲蓝（MB）作为模型药物，在负载MB的泊洛沙姆水凝胶以及负载MB的藻酸盐微粒/泊洛沙姆水凝胶复合系统中进行药物释放研究。后者的MB释放速度明显比前者慢（10倍），表明其在开发用于药物递送或组织工程的双载药释放系统方面具有潜力。
