Van Tam T, Cox Laura M, Cox Mike E, Dien Bard Jennifer
Department of Pathology and Laboratory Medicine, Children's Hospital Los Angeles, Los Angeles, California, USA.
Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
J Clin Microbiol. 2017 Apr;55(4):1147-1153. doi: 10.1128/JCM.02174-16. Epub 2017 Jan 25.
, an obligate anaerobic bacterium, was recently reported to be an important cause of bacterial pharyngitis with a prevalence as high as that of group A (GAS) in adolescents and young adults. Importantly, is the primary causative agent of the life-threatening Lemierre's syndrome, and screening of pharyngeal samples may be warranted for its early detection and prevention. The aim of this study was to determine the prevalences of and groups A and C/G streptococci as agents of bacterial pharyngitis in children. Pharyngeal samples ( = 300) were collected from pediatric patients presenting to the emergency department with signs and symptoms of pharyngitis. Overall, 10 (3.3%), 79 (26.3%), and 4 (1.3%) patients were PCR positive for , GAS, and group C/G streptococci, respectively. The prevalence of was significantly higher in patients between the ages of 14 and 20 years at 13.5% than in patients aged 14 years and younger (1.9%, < 0.001). All positive patients presented with signs and symptoms similar to GAS pharyngitis. Our data demonstrated a potential role for as a pathogen of pharyngitis among young adults, but suggests that the prevalence of is low in preadolescent patients.
一种专性厌氧菌，最近被报道是细菌性咽炎的重要病因，在青少年和年轻成年人中的患病率与A组（GAS）相当。重要的是，它是危及生命的勒米耶综合征的主要病原体，因此对咽拭子样本进行筛查可能有助于早期发现和预防。本研究的目的是确定在儿童中作为细菌性咽炎病原体的该菌以及A组和C/G组链球菌的患病率。从因咽炎症状就诊于急诊科的儿科患者中收集咽拭子样本（n = 300）。总体而言，分别有10例（3.3%）、79例（26.3%）和4例（1.3%）患者的该菌、GAS和C/G组链球菌PCR检测呈阳性。14至20岁患者中该菌的患病率显著高于14岁及以下患者（分别为13.5%和1.9%，P <0.001）。所有阳性患者均表现出与GAS咽炎相似的症状和体征。我们的数据表明该菌在年轻成年人中作为咽炎病原体具有潜在作用，但提示在青春期前患者中该菌的患病率较低。
