Mitsios Alexandros, Arampatzioglou Athanasios, Arelaki Stella, Mitroulis Ioannis, Ritis Konstantinos
Laboratory of Molecular Hematology, Democritus University of Thrace , Alexandroupolis , Greece.
Laboratory of Molecular Hematology, Democritus University of Thrace, Alexandroupolis, Greece; Department of Pathology, University General Hospital of Alexandroupolis, Alexandroupolis, Greece.
Front Immunol. 2017 Jan 11;7:678. doi: 10.3389/fimmu.2016.00678. eCollection 2016.
Neutrophil extracellular traps (NETs) were initially described as an antimicrobial mechanism of neutrophils. Over the last decade, several lines of evidence support the involvement of NETs in a plethora of pathological conditions. Clinical and experimental data indicate that NET release constitutes a shared mechanism, which is involved in a different degree in various manifestations of non-infectious diseases. Even though the backbone of NETs is similar, there are differences in their protein load in different diseases, which represent alterations in neutrophil protein expression in distinct disorder-specific microenvironments. The characterization of NET protein load in different NET-driven disorders could be of significant diagnostic and/or therapeutic value. Additionally, it will provide further evidence for the role of NETs in disease pathogenesis, and it will enable the characterization of disorders in which neutrophils and NET-dependent inflammation are of critical importance.
中性粒细胞胞外诱捕网（NETs）最初被描述为中性粒细胞的一种抗菌机制。在过去十年中，多条证据支持NETs参与了众多病理状况。临床和实验数据表明，NET释放是一种共同机制，在非感染性疾病的各种表现中不同程度地发挥作用。尽管NETs的主干相似，但在不同疾病中其蛋白质负载存在差异，这代表了在不同疾病特异性微环境中中性粒细胞蛋白质表达的改变。对不同NET驱动疾病中NET蛋白质负载的表征可能具有重要的诊断和/或治疗价值。此外，它将为NETs在疾病发病机制中的作用提供进一步证据，并能够对中性粒细胞和NET依赖性炎症至关重要的疾病进行表征。
