Alsaegh Mohammed Amjed, Miyashita Hitoshi, Taniguchi Takahiro, Zhu Sheng Rong
Department of Oral and Maxillofacial Surgery, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, P.R. China; Department of Oral and Maxillofacial Surgery, College of Dentistry, Ajman University, Al-Hulifat, Fujairah 2202, UAE; Department of Oral and Maxillofacial Surgery, College of Dentistry, University of Mosul, Mosul, Ninavah 41002, Iraq.
Department of Oral and Maxillofacial Surgery, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, P.R. China; Department of Oral Medicine and Surgery, Division of Oral and Maxillofacial Surgery, Graduate School of Dentistry, Tohoku University, Sendai 980-8575, Japan.
Exp Ther Med. 2017 Jan;13(1):247-253. doi: 10.3892/etm.2016.3939. Epub 2016 Dec 1.
Investigation of cyclooxygenase (COX)-2 in dentigerous cyst and ameloblastoma may help to improve understanding of the nature and behavior of odontogenic cysts and tumors, and in addition may eventually represent a definitive target for a pharmacological approach in the management of these lesions. The aim of this study was to evaluate COX-2 expression and its correlation with the proliferation of odontogenic epithelium in these lesions. Dentigerous cysts (n=16) and ameloblastomas (n=17) were evaluated. Detection of Ki-67 and COX-2 protein expression was conducted by immunohistochemistry. Data were statistically analyzed using Mann-Whitney U test and Spearman's rank correlation coefficient. No significant differences were found in the expression of Ki-67 and COX-2 between dentigerous cysts and ameloblastomas (P>0.05). A significant positive correlation (P=0.018) and highly significant positive correlation (P=0.004) were found between Ki-67 and COX-2 expression in the odontogenic epithelium of dentigerous cyst and ameloblastoma, respectively. COX-2 was expressed in the odontogenic epithelium of dentigerous cyst and ameloblastoma. It may contribute to local extension of these lesions by increasing the proliferation of their odontogenic epithelial cells.
对含牙囊肿和成釉细胞瘤中环氧合酶（COX）-2的研究可能有助于增进对牙源性囊肿和肿瘤的性质及行为的理解，此外最终可能成为这些病变治疗中药物治疗方法的一个明确靶点。本研究的目的是评估COX-2在这些病变中的表达及其与牙源性上皮增殖的相关性。对含牙囊肿（n = 16）和成釉细胞瘤（n = 17）进行了评估。通过免疫组织化学检测Ki-67和COX-2蛋白表达。使用Mann-Whitney U检验和Spearman等级相关系数对数据进行统计学分析。含牙囊肿和成釉细胞瘤之间在Ki-67和COX-2的表达上未发现显著差异（P>0.05）。在含牙囊肿和成釉细胞瘤的牙源性上皮中，Ki-67与COX-2表达之间分别发现显著正相关（P = 0.018）和高度显著正相关（P = 0.004）。COX-2在含牙囊肿和成釉细胞瘤的牙源性上皮中表达。它可能通过增加其牙源性上皮细胞的增殖而促进这些病变的局部扩展。
