中国南方自闭症谱系障碍患儿的新生儿总胆红素（TSB）、神经元特异性烯醇化酶（NSE）和肌酸激酶同工酶BB（CK-BB）水平。
The neonatal levels of TSB, NSE and CK-BB in autism spectrum disorder from Southern China.
作者信息
Lv Meng-Na, Zhang Hong, Shu Yi, Chen Shan, Hu Yuan-Yuan, Zhou Min
机构信息
Department of Neurology, Zhongnan Hospital of Wuhan University, Wuhan 430071, P. R. China.
Department of Neurology, Zhongnan Hospital of Wuhan University, Wuhan 430071, P. R. China; Teaching and research section of Neuropsychiatry, Zhongnan Hospital of Wuhan University, Wuhan 430071, P. R. China.
出版信息
Transl Neurosci. 2016 Feb 18;7(1):6-11. doi: 10.1515/tnsci-2016-0002. eCollection 2016.
UNLABELLED
Background" Autism spectrum disorder (ASD) is a serious neurodevelopmental disorder that impairs a child's ability to communicate with others. It also includes restricted repetitive behaviors, interests and activities. Symptoms manifest before the age of 3. In the previous studies, we found structural abnormalities of the temporal lobe cortex. High spine densities were most commonly found in ASD subjects with lower levels of cognitive functioning. In the present study, we retrospectively analyzed medical records in relation to the neonatal levels of total serum bilirubin (TSB), neuron-specific enolase (NSE), creatine kinase brain band isoenzyme (CK-BB), and neonatal behavior in ASD patients from Southern China.
METHODS
A total of 80 patients with ASD (ASD group) were screened for this retrospective study. Among them, 34 were low-functioning ASD (L-ASD group) and 46 were high-functioning ASD (H-ASD group). Identification of the ASD cases was confirmed with a Revised Autism Diagnostic Inventory. For comparison with ASD cases, 80 normal neonates (control group) were selected from the same period. Biochemical parameters, including TSB, NSE and CK-BB in the neonatal period and medical records on neonatal behavior were collected.
RESULTS
The levels of serum TSB, NSE and CK-BB in the ASD group were significantly higher when compared with those from the control group (P < 0.01, or P < 0.05). The amounts of serum TSB, NSE and CK-BB in the L-ASD group were significantly higher when compared with those in the H-ASD group (P < 0.01, or P < 0.05). The Neonatal Behavioral Assessment Scale (NBAS) scores in the ASD group were significantly lower than that in the control group (P < 0.05). Likewise, the NBAS scores in the L-ASD group were significantly lower than that in the H-ASD group (P < 0.05). There was no association between serum TSB, NSE, CK-BB and NBAS scores (P > 0.05) in the ASD group.
CONCLUSIONS
The neonatal levels of TSB, NSE and CK-BB in ASD from Southern China were significantly higher than those of healthy controls. These findings need to be investigated thoroughly by future studies with large sample.
未标注
背景：自闭症谱系障碍（ASD）是一种严重的神经发育障碍，会损害儿童与他人交流的能力。它还包括受限的重复行为、兴趣和活动。症状在3岁之前出现。在先前的研究中，我们发现颞叶皮质存在结构异常。高脊柱密度最常见于认知功能较低的ASD患者。在本研究中，我们回顾性分析了中国南方ASD患者的医疗记录，涉及新生儿血清总胆红素（TSB）、神经元特异性烯醇化酶（NSE）、肌酸激酶脑型同工酶（CK-BB）水平以及新生儿行为。
方法
本回顾性研究共筛查了80例ASD患者（ASD组）。其中，34例为低功能ASD（L-ASD组），46例为高功能ASD（H-ASD组）。ASD病例通过修订版自闭症诊断量表进行确诊。为与ASD病例进行比较，同期选取了80例正常新生儿（对照组）。收集了新生儿期的生化参数，包括TSB、NSE和CK-BB以及新生儿行为的医疗记录。
结果
与对照组相比，ASD组的血清TSB、NSE和CK-BB水平显著更高（P<0.01或P<0.05）。与H-ASD组相比，L-ASD组的血清TSB、NSE和CK-BB含量显著更高（P<0.01或P<0.05）。ASD组的新生儿行为评估量表（NBAS）评分显著低于对照组（P<0.05）。同样，L-ASD组的NBAS评分显著低于H-ASD组（P<0.05）。ASD组中血清TSB、NSE、CK-BB与NBAS评分之间无关联（P>0.05）。
结论
中国南方ASD患者的新生儿TSB、NSE和CK-BB水平显著高于健康对照组。这些发现需要未来大样本研究进行深入调查。
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