Kyburz Andreas, Müller Anne
Institute of Molecular Cancer Research, University of Zürich, Winterthurerstr. 190, 8057, Zurich, Switzerland.
Curr Top Microbiol Immunol. 2017;400:325-347. doi: 10.1007/978-3-319-50520-6_14.
The Gram-negative bacterium Helicobacter pylori is predominantly known for its tight association with peptic ulcer disease and gastric cancer development. However, recent epidemiological and experimental evidence suggests that chronic infection with H. pylori may at the same time be beneficial to the host by conferring protection against gastroesophageal diseases, asthma, other allergic disease manifestations and inflammatory bowel diseases (IBD). In this chapter, we summarize the epidemiological data that are available to date to support or refute a possible inverse correlation of H. pylori infection with various extragastric diseases. We further examine and discuss the experimental evidence, generated mostly in mouse models of allergic diseases and IBD, showing that these disorders fail to develop in the presence of H. pylori. The proposed mechanisms of the protective effects of H. pylori, which appear to involve the induction of regulatory T-cells (Tregs) with highly suppressive activity, are presented and explained.
革兰氏阴性菌幽门螺杆菌主要因其与消化性溃疡疾病和胃癌发展的紧密关联而闻名。然而，最近的流行病学和实验证据表明，幽门螺杆菌的慢性感染可能同时通过提供针对胃食管疾病、哮喘、其他过敏性疾病表现和炎症性肠病（IBD）的保护作用而对宿主有益。在本章中，我们总结了迄今为止可获得的流行病学数据，以支持或反驳幽门螺杆菌感染与各种胃外疾病之间可能存在的负相关关系。我们进一步研究和讨论主要在过敏性疾病和IBD小鼠模型中产生的实验证据，这些证据表明在幽门螺杆菌存在的情况下这些疾病不会发生。文中还介绍并解释了幽门螺杆菌保护作用的拟议机制，这似乎涉及诱导具有高度抑制活性的调节性T细胞（Tregs）。
