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共生菌、共生体还是病原体?

: Commensal, symbiont or pathogen?

作者信息

Reshetnyak Vasiliy Ivanovich, Burmistrov Alexandr Igorevich, Maev Igor Veniaminovich

机构信息

Department of Propaedeutic of Internal Diseases and Gastroenterology, A.I. Yevdokimov Moscow State University of Medicine and Dentistry, Moscow 127473, Russia.

出版信息

World J Gastroenterol. 2021 Feb 21;27(7):545-560. doi: 10.3748/wjg.v27.i7.545.

DOI:10.3748/wjg.v27.i7.545
PMID:33642828
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7901052/
Abstract

This review considers the data on () which have been accumulated over 40 years since its description as an etiological factor in gastrointestinal diseases. The majority of modern publications are devoted to the study of the pathogenic properties of the microorganism in the development of chronic gastritis, peptic ulcer disease, and gastric cancer, as well as methods for its eradication. However, in recent years, there have been more and more studies which have suggested that has a beneficial, or potentially positive, effect on the human body. The authors have attempted to objectively analyze the information accumulated in the literature on . Some studies consider it as one of the recently identified human bacterial pathogens, and special attention is paid to the evidence suggesting that it is probably part of the composition of the human microbiome as a commensal ( from French to English is a table companion) or even a symbiont. The presented data discussing the presence or absence of the effect of on human health suggest that there is an apparent ambiguity of the problem. The re-assessment of the data available on infection is important in order to answer the question of whether it is necessary to create a program of mass eradication or to apply a more personalized approach to treating patients with -associated gastrointestinal diseases and to perform eradication therapy.

摘要

本综述考虑了自其被描述为胃肠道疾病的病因以来40多年间积累的关于()的数据。大多数现代出版物致力于研究该微生物在慢性胃炎、消化性溃疡疾病和胃癌发展中的致病特性,以及根除它的方法。然而,近年来,越来越多的研究表明()对人体有有益的或潜在积极的影响。作者试图客观分析文献中积累的关于()的信息。一些研究将其视为最近发现的人类细菌病原体之一,并且特别关注表明它可能作为共生菌(从法语到英语是餐桌同伴)甚至共生体成为人类微生物组组成部分的证据。所呈现的讨论()对人类健康有无影响的数据表明,这个问题明显存在模糊性。重新评估关于()感染的现有数据对于回答是否有必要制定大规模根除()计划,或者对患有与()相关胃肠道疾病的患者采用更个性化的治疗方法并进行根除治疗这一问题很重要。

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