采用持续静静脉血液滤过治疗头孢呋辛引起的神经毒性。
Treatment of cefuroxime-induced neurotoxicity with continuous venovenous haemofiltration.
作者信息
van Dam D G H A, Burgers D M T, Foudraine N, Janssen P K C, Neef C, le Noble J L M L
机构信息
Department of Intensive Care, VieCuri Medical Centre, the Netherlands.
出版信息
Neth J Med. 2017 Jan;75(1):32-34.
A 61-year-old woman with decreased consciousness, myoclonus, tremors, nystagmus and bradypnoea, due to cefuroxime-induced neurotoxicity, was admitted to the intensive care unit. Continuous venovenous haemofiltration (CVVH) rapidly reduced plasma cefuroxime concentrations and improved neurological manifestations within the next few hours. Retrospective pharmacokinetic assessment showed a total cefuroxime clearance of 166 ml/min during the CVVH.
一名61岁女性因头孢呋辛诱导的神经毒性出现意识减退、肌阵挛、震颤、眼球震颤和呼吸过缓，被收入重症监护病房。持续静脉-静脉血液滤过（CVVH）迅速降低了血浆头孢呋辛浓度，并在接下来的几个小时内改善了神经学表现。回顾性药代动力学评估显示，CVVH期间头孢呋辛的总清除率为166 ml/分钟。
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