Louis S M, Johnstone D, Russell N J, Jamieson A, Dockray G J
MRC Secretory Control Group, Physiological Laboratory, University of Liverpool, U.K.
Neurosci Lett. 1989 Jul 31;102(2-3):257-60. doi: 10.1016/0304-3940(89)90088-8.
The influence of prior immunization to calcitonin gene-related peptide (CGRP) was examined on responses in two models of inflammation plasma: protein extravasation following topical application of mustard oil to the hind paw, and changes in paw volume following subplantar injection of carrageenin. In rats with antibodies to CGRP, there was an approximately 50% decrease compared to the control animals in extravasation, measured by the Evans blue method after topical mustard oil. In contrast, there was no difference in the inflammatory response to carrageenin in control and immunized rats. The results indicate that CGRP, which is probably released from the peripheral endings of cutaneous primary afferents, plays a role in the inflammatory response to mustard oil, but not carrageenin.
研究了预先免疫降钙素基因相关肽（CGRP）对两种炎症模型反应的影响：一是在大鼠后爪局部涂抹芥子油后血浆蛋白外渗，二是在大鼠足底注射角叉菜胶后爪体积的变化。在用抗CGRP抗体处理的大鼠中，通过在局部涂抹芥子油后用伊文思蓝法测量，与对照动物相比，外渗减少了约50%。相比之下，对照大鼠和免疫大鼠对角叉菜胶的炎症反应没有差异。结果表明，可能从皮肤初级传入神经外周末梢释放的CGRP在对芥子油的炎症反应中起作用，但在对角叉菜胶的炎症反应中不起作用。
