Kawamura M, Kuraishi Y, Minami M, Satoh M
Department of Pharmacology, Faculty of Pharmaceutical Science, Kyoto University, Japan.
Brain Res. 1989 Sep 11;497(1):199-203. doi: 10.1016/0006-8993(89)90990-6.
We compared the effects of intrathecal administration of antiserum against calcitonin gene-related peptide (CGRP) between thermo- and mechano-nociceptive responses, using experimental hyperalgesic rats. An intrathecal administration of anti-CGRP antiserum, but not antiserum absorbed by synthetic CGRP, normalized either adjuvant- or carrageenin-induced hyperalgesia both in the paw radiant heat and the paw pressure tests, with little effect on non-hyperalgesic paws. These results suggest that endogenous CGRP, probably present in primary afferents, promotes both thermo- and mechano-nociceptive transmission in the spinal dorsal horn, at least in the hyperalgesic states with inflammations.
我们使用实验性痛觉过敏大鼠，比较了鞘内注射降钙素基因相关肽（CGRP）抗血清对热痛觉和机械性痛觉反应的影响。鞘内注射抗CGRP抗血清，而非被合成CGRP吸收的抗血清，可使佐剂或角叉菜胶诱导的痛觉过敏在爪部辐射热和爪部压力测试中恢复正常，对非痛觉过敏的爪部影响很小。这些结果表明，内源性CGRP可能存在于初级传入神经中，至少在炎症引起的痛觉过敏状态下，可促进脊髓背角的热痛觉和机械性痛觉传递。
