Department of CT, Shandong Medical Imaging Research Institute, Shandong University, #324 Jingwu Road, Jinan, 250021, PR China; Department of Radiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, #167 Bei-Li-Shi Street, Beijing, 100037, PR China.
Department of Radiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, #167 Bei-Li-Shi Street, Beijing, 100037, PR China.
J Cardiovasc Comput Tomogr. 2017 Mar-Apr;11(2):105-110. doi: 10.1016/j.jcct.2017.01.003. Epub 2017 Jan 17.
To compare the difference of coronary diameter stenosis by quantitative analysis of CT angiography (QCT) in the systolic (QCT-S) and diastolic phase (QCT-D) of the cardiac cycle, with invasive catheter angiography (QCA) as reference standard.
A total of 109 patients (57.5 ± 10.6 years, 78.9% male) with suspected coronary artery disease (CAD) who underwent both CT angiography and invasive catheter angiography were retrospectively included in this study. Coronary diameter stenoses in systolic and diastolic coronary CTA reconstructions were compared with QCA.
Mean time interval between CT angiography and invasive angiography was 17.4 ± 4.4 days. QCT-D overestimated coronary diameter stenosis by 5.7%-8.5% while QCT-S overestimated coronary diameter stenosis by 9.4%-11.9% (p < 0.05). In calcified lesions, QCT-D overestimated coronary diameter stenosis by 13.2 ± 4.3%, while QCT-S overestimated by stenosis by 16.6 ± 4.3% (p < 0.05).
Coronary diameter stenosis was overestimated by QCT-D as well as QCT-S, respectively, when compared with QCA. Overestimation was more pronounced in calcified lesions.
通过比较心脏周期收缩期（QCT-S）和舒张期（QCT-D）定量 CT 血管造影（QCT）测量的冠状动脉直径狭窄程度与有创导管血管造影（QCA）的差异，作为参考标准。
回顾性纳入了 109 例疑似冠心病（CAD）患者（57.5±10.6 岁，78.9%为男性），这些患者均接受了 CT 血管造影和有创导管血管造影检查。比较了收缩期和舒张期冠状动脉 CTA 重建的冠状动脉直径狭窄程度与 QCA。
CT 血管造影和有创血管造影之间的平均时间间隔为 17.4±4.4 天。QCT-D 高估了 5.7%-8.5%的冠状动脉直径狭窄程度，而 QCT-S 高估了 9.4%-11.9%（p<0.05）。在钙化病变中，QCT-D 高估了 13.2±4.3%的冠状动脉直径狭窄程度，而 QCT-S 高估了 16.6±4.3%（p<0.05）。
与 QCA 相比，QCT-D 和 QCT-S 分别高估了冠状动脉直径狭窄程度。在钙化病变中，高估程度更为明显。
