Darbinyan L V, Hambardzumyan L E, Simonyan K V, Chavushyan V A, Manukyan L P, Sarkisian V H
Sensorimotor Integration Lab, Orbeli Institute of Physiology NAS RA, Yerevan, 0028, Armenia.
Neuroendocrine Relationships Lab, Orbeli Institute of Physiology NAS RA, Yerevan, 0028, Armenia.
Pathophysiology. 2017 Mar;24(1):23-30. doi: 10.1016/j.pathophys.2017.01.001. Epub 2017 Jan 22.
Parkinson's disease (PD) is the most common neurodegenerative disease of unknown etiology and characterized by motor symptoms of tremor, rigidity, bradykinesia, and postural instability. Interactions between the dopaminergic systems and the hippocampus in synaptic plasticity and behavior are found. The rotenone-induced animal model is commonly used in research studies involved in PD. Administration of rotenone causes alterations of electrical neuronal activity. Rotenone (2.5 mg/kg/day) was administered intraperitoneally for 21 days to adult rats, and rotenone effects on rearing activity and electrophysiology were examined. Dose-dependent reduction of evoked neural activity and a reduction in firing strength were found in the hippocampus. Behaviorally, Rotenone rats showed a more consistent decrease in rearing across the 3 weeks, compared with animals in the control group. Thus, rotenone causes changes in hippocampal electrical activity and behavioral changes.
帕金森病（PD）是最常见的病因不明的神经退行性疾病，其特征为震颤、僵硬、运动迟缓及姿势不稳等运动症状。已发现多巴胺能系统与海马体在突触可塑性和行为方面存在相互作用。鱼藤酮诱导的动物模型常用于帕金森病相关的研究。给予鱼藤酮会导致神经元电活动改变。将鱼藤酮（2.5毫克/千克/天）腹腔注射成年大鼠21天，并检测鱼藤酮对竖毛活动和电生理学的影响。结果发现海马体中诱发神经活动呈剂量依赖性降低，放电强度也降低。在行为方面，与对照组动物相比，鱼藤酮处理的大鼠在3周内竖毛活动的减少更为持续。因此，鱼藤酮会引起海马体电活动变化和行为改变。
