Darbinyan L V, Simonyan K V, Hambardzumyan L E, Manukyan L P, Badalyan S H, Sarkisian V H
Sensorimotor Integration Laboratory, Orbeli Institute of Physiology NAS RA, 0028, Yerevan, Armenia.
Neuroendocrine Relationships Laboratory, Orbeli Institute of Physiology NAS RA, 0028, Yerevan, Armenia.
Metab Brain Dis. 2022 Apr;37(4):1111-1118. doi: 10.1007/s11011-022-00941-6. Epub 2022 Mar 3.
Rotenone is involved in the degeneration of dopaminergic neurons, and curcumin may prevent or effectively slow the progression of Parkinson's disease (PD). Previous research has shown that the naturally occurring phenolic compound curcumin can reduce inflammation and oxidation, making it a potential therapeutic agent for neurodegenerative diseases. The present study involves investigation of rotenone-induced histological changes in the brain area, hippocampus using Nissl staining after 35 day of subcutaneous injection of rotenone in adult male rats. We sought to determine whether curcumin could protect against rotenone-induced dopaminergic neurotoxicity in a rat model by in vivo electrical recording from Substantia nigra pars compacta (SNc). Curcumin treatment significantly improved electrical activity of neurons in the SNc of rotenone-induced PD model rats. The pattern of histological alterations corresponds with electrophysiological manifestations.
鱼藤酮参与多巴胺能神经元的退化，而姜黄素可能预防或有效减缓帕金森病（PD）的进展。先前的研究表明，天然存在的酚类化合物姜黄素可以减轻炎症和氧化，使其成为神经退行性疾病的潜在治疗剂。本研究涉及在成年雄性大鼠皮下注射鱼藤酮35天后，使用尼氏染色法研究鱼藤酮诱导的脑区（海马体）组织学变化。我们试图通过对黑质致密部（SNc）进行体内电记录，来确定姜黄素是否能在大鼠模型中预防鱼藤酮诱导的多巴胺能神经毒性。姜黄素治疗显著改善了鱼藤酮诱导的帕金森病模型大鼠SNc中神经元的电活动。组织学改变模式与电生理表现相对应。
