Dolsen Michael R, Harvey Allison G
Department of Psychology, University of California, Berkeley, USA.
Addiction. 2017 Jun;112(6):1104-1111. doi: 10.1111/add.13772. Epub 2017 Feb 28.
To examine the association between a life-time history of insomnia and hypersomnia compared with no sleep disturbance and substance use patterns and amounts before and after a substance use treatment episode.
Secondary analysis of data from the Drug Abuse Treatment Outcome Studies conducted from 1991 to 1994.
Data were collected at 96 substance use treatment programs in 11 United States cities, including short-term in-patient, long-term residential, methadone maintenance and out-patient drug-free treatment modalities.
Study samples included 7168 adults at treatment entry and 2965 at 12 months post-treatment entry whose primary substance use at entry was alcohol (14.7%), cocaine (62.7%) or heroin (22.6%).
Life-time history of insomnia and hypersomnia was assessed via self-report. Type and frequency of substance use were assessed at treatment entry. Substance use was also assessed 12 months following treatment completion. Associations were examined using linear and logistic regression with age, sex, race, education level, depression history, treatment modality and in-treatment substance use as covariates.
Life-time history of insomnia, hypersomnia, both or neither was reported by 26.3, 9.5, 28.0 and 36.2% of participants, respectively. Compared with no sleep disturbance, life-time insomnia and hypersomnia were associated at treatment entry with unique substance use patterns and a higher frequency of any substance use (P < 0.001). All types of sleep disturbance were associated with higher rates of cocaine use at 12-month post-entry (odds ratios: 1.30-1.57).
There is evidence of an adverse association between substance use and sleep disturbance including higher frequency of all substance use before substance abuse treatment and higher rates of cocaine use after a treatment episode.
与无睡眠障碍相比,研究失眠和嗜睡的终生病史与物质使用治疗期间及之后的物质使用模式和使用量之间的关联。
对1991年至1994年进行的药物滥用治疗结果研究中的数据进行二次分析。
在美国11个城市的96个物质使用治疗项目中收集数据,包括短期住院、长期住院、美沙酮维持治疗和门诊戒毒治疗模式。
研究样本包括7168名治疗开始时的成年人以及2965名治疗开始后12个月的成年人,他们在开始时的主要物质使用情况为酒精(14.7%)、可卡因(62.7%)或海洛因(22.6%)。
通过自我报告评估失眠和嗜睡的终生病史。在治疗开始时评估物质使用的类型和频率。在治疗结束后12个月也评估物质使用情况。使用线性和逻辑回归分析关联,将年龄、性别、种族、教育水平、抑郁病史、治疗模式和治疗期间的物质使用作为协变量。
分别有26.3%、9.5%、28.0%和36.2%的参与者报告有失眠、嗜睡、两者皆有或两者皆无的终生病史。与无睡眠障碍相比,终生失眠和嗜睡在治疗开始时与独特的物质使用模式以及任何物质使用的较高频率相关(P<0.001)。所有类型的睡眠障碍在进入后12个月时都与可卡因使用的较高发生率相关(比值比:1.30 - 1.57)。
有证据表明物质使用与睡眠障碍之间存在不良关联,包括在药物滥用治疗前所有物质使用的频率较高,以及在治疗期间后可卡因使用的发生率较高。