Riis Peter Theut, Ring Hans Christian, Themstrup Lotte, Jemec Gregor Borut
Peter Theut Riis, MD, Department of Dermatology University Hospital Zealand, Køgevej 7-13, 4000 Roskilde, Denmark;
Acta Dermatovenerol Croat. 2016 Dec;24(4):239-249.
Hidradenitis suppurativa (HS) is an inflammatory skin disease. Several observations imply that sex hormones may play a role in its pathogenesis. HS is more common in women, and the disease severity appears to vary in intensity according to the menstrual cycle. In addition, parallels have been drawn between HS and acne vulgaris, suggesting that sex hormones may play a role in the condition. The role of androgens and estrogens in HS has therefore been explored in numerous observational and some interventional studies; however, the studies have often reported conflicting results. This systematic review includes 59 unique articles and aims to give an overview of the available research. Articles containing information on natural variation, severity changes during menstruation and pregnancy, as well as articles on serum levels of hormones in patients with HS and the therapeutic options of hormonal manipulation therapy have all been included and are presented in this systematic review. Our results show that patients with HS do not seem to have increased levels of sex hormones and that their hormone levels lie within the normal range. While decreasing levels of progesterone and estrogen seem to coincide with disease flares in premenopausal women, the association is speculative and requires experimental confirmation. Antiandrogen treatment could be a valuable approach in treating HS, however randomized control trials are lacking.
化脓性汗腺炎（HS）是一种炎症性皮肤病。多项观察结果表明，性激素可能在其发病机制中起作用。HS在女性中更为常见，并且疾病严重程度似乎会根据月经周期而有所不同。此外，HS与寻常痤疮之间存在相似之处，这表明性激素可能在该病中起作用。因此，在众多观察性研究和一些干预性研究中探讨了雄激素和雌激素在HS中的作用；然而，这些研究往往报告了相互矛盾的结果。本系统评价纳入了59篇独特的文章，旨在对现有研究进行概述。包含自然变异、月经和孕期严重程度变化信息的文章，以及关于HS患者血清激素水平和激素操纵疗法治疗选择的文章均已纳入本系统评价并呈现。我们的结果表明，HS患者的性激素水平似乎并未升高，且其激素水平处于正常范围内。虽然绝经前女性孕酮和雌激素水平的下降似乎与疾病发作同时出现，但这种关联只是推测性的，需要实验证实。抗雄激素治疗可能是治疗HS的一种有价值的方法，然而缺乏随机对照试验。
