Piętowska-Marczak Zuzanna, Krefft-Trzciniecka Katarzyna, Pakiet Alicja, Nowicka Danuta
Department of Aesthetic Dermatology and Regenerative Skin Medicine, Wrocław Medical University, 50-556 Wrocław, Poland.
University Center for General and Oncological Dermatology, Wrocław Medical University, 50-556 Wrocław, Poland.
J Clin Med. 2025 Apr 17;14(8):2760. doi: 10.3390/jcm14082760.
: Hidradenitis suppurativa (HS) is a rare, debilitating, chronic inflammatory skin disease. This study aimed to investigate differences in body composition between patients with hidradenitis suppurativa (HS) and healthy controls, with a particular focus on sex-specific disparities, while also exploring secondary associations with muscle health and quality of life. : Body composition was measured using a bioanalyzer and compared between HS individuals ( = 53) and controls ( = 50). The mean BMI was significantly higher in the HS group than in the controls (median 29.6 vs. median 22.1; < 0.001, effect size -0.581). The patients with HS had a significantly higher fat mass (mean 26.2 ± 22.7 vs. 16.3 ± 6.0; < 0.001, effect size -0.400), level of visceral fat (median 9 vs. 2; < 0.001, effect size -0.473), percentage of total body water (mean 45.9 ± 12.3 vs. 31.9 ± 14.3; < 0.001, effect size -0.508), skeletal muscle index (median 8.9 vs. 7.3; < 0.001, effect size -0.445), and bone mass (median 3.2 vs. 2.5; < 0.001, effect size -0.421); at the same time, they had a significantly lower predicted muscle mass (median 19.8 vs. 47.3; < 0.001, effect size -0.740) and percentage of skeletal muscle mass (mean 38.2 ± 7.8 vs. 42.3 ± 5.5; = 0.008, effect size -0.263) in comparison to the controls. The HS group was also characterized by a higher metabolic age (median 65 vs. 21 years; < 0.001, effect size -0.760) and basal metabolic rate (median 1927 vs. 1489 kcal; < 0.001, effect size -0.444). : Patients with HS exhibit a distinctive pattern in body composition parameters when compared to healthy controls, which may hold significant potential for enhancing diagnostic accuracy and monitoring disease progression. This study highlighted sex-specific differences in body composition, emphasizing the need to consider biological sex in the pathophysiology and clinical evaluation of HS. Further research is needed to explore the clinical utility of body composition analysis in disease progression, therapeutic response, and personalized management.
化脓性汗腺炎（HS）是一种罕见的、使人衰弱的慢性炎症性皮肤病。本研究旨在调查化脓性汗腺炎（HS）患者与健康对照者之间身体成分的差异，特别关注性别差异，同时探讨与肌肉健康和生活质量的次要关联。使用生物分析仪测量身体成分，并在HS个体（n = 53）和对照者（n = 50）之间进行比较。HS组的平均BMI显著高于对照组（中位数29.6对中位数22.1；P < 0.001，效应大小-0.581）。HS患者的脂肪量显著更高（平均值26.2±22.7对16.3±6.0；P < 0.001，效应大小-0.400）、内脏脂肪水平（中位数9对2；P < 0.001，效应大小-0.473）、全身水百分比（平均值45.9±12.3对31.9±14.3；P < 0.001，效应大小-0.508）、骨骼肌指数（中位数8.9对7.3；P < 0.001，效应大小-0.445）和骨量（中位数3.2对2.5；P < 0.001，效应大小-0.421）；同时，与对照组相比，他们的预测肌肉量显著更低（中位数19.8对47.3；P < 0.001，效应大小-0.740）和骨骼肌质量百分比（平均值38.2±7.8对42.3±5.5；P = 0.008，效应大小-0.263）。HS组的特征还包括更高的代谢年龄（中位数65对21岁；P < 0.001，效应大小-0.760）和基础代谢率（中位数1927对1489千卡；P < 0.001，效应大小-0.444）。与健康对照者相比，HS患者在身体成分参数方面表现出独特的模式，这可能在提高诊断准确性和监测疾病进展方面具有巨大潜力。本研究强调了身体成分的性别差异，强调在HS的病理生理学和临床评估中需要考虑生物学性别。需要进一步研究以探索身体成分分析在疾病进展、治疗反应和个性化管理中的临床应用。
