Dogra Jaideep, Lal Bhupender Behari, Misra Shyam Nath
Indian J Dermatol Venereol Leprol. 1989 Nov-Dec;55(6):375-377.
In India, contaneous leishmaniasis is confined to the western Thar desert. Epidemiologically, two different forms are seen, viz the rural and the urban forms. The vectors responsible for the transmission in this region are the Phlebotomus papatasi and the Sergentomyia clydei. The efficacy of oral dapsone was evaluated in the commonly existing sub-types of cutaneous leishmaniasis. Ten patients each of the nodular and ulcerative forms of cutaneous leishmaniasis were selected by strict 'clinical and pathological criteria and treated with oral dapsone in a dose of 2 mg per kg body weight daily, for 6 weeks. Seven patients of the nodular variety and all the ten patients in the ulcerative sub-group were cured. No major adverse effects were noted. Review after 6 months revealed no recurrence. in another ten patients taken as controls and not receiving the drug, the lesions showed no significant change.
在印度，皮肤利什曼病局限于西部塔尔沙漠地区。从流行病学角度来看，存在两种不同形式，即农村型和城市型。该地区负责传播的病媒是巴氏白蛉和克莱德司蛉。对口服氨苯砜在常见的皮肤利什曼病亚型中的疗效进行了评估。通过严格的“临床和病理标准，挑选出10例结节型和10例溃疡型皮肤利什曼病患者，每天按每公斤体重2毫克的剂量口服氨苯砜，治疗6周。结节型的7例患者和溃疡型亚组的所有10例患者均治愈。未观察到重大不良反应。6个月后复查未发现复发情况。另外10例作为对照未接受药物治疗的患者，其皮损无明显变化。
