Dogra J, Lal B B, Misra S N
Int J Dermatol. 1986 Jul-Aug;25(6):398-400. doi: 10.1111/j.1365-4362.1986.tb03435.x.
Fifty patients with cutaneous leishmaniasis were treated with dapsone (DDS) approximately 2 mg per kilogram body weight per day for 21 days. Forty patients (80%) were declared cured on the basis of clinical and pathologic criteria. Follow-up examination after 6 months revealed no recurrences. No major side effects were noted. In the control group of 15 patients not receiving the drug, no significant change was seen in the lesions. Dapsone thus was used successfully for the first time.
五十名皮肤利什曼病患者接受了氨苯砜(DDS)治疗,剂量约为每日每公斤体重2毫克,持续21天。根据临床和病理标准,四十名患者(80%)被宣布治愈。6个月后的随访检查未发现复发情况。未观察到严重副作用。在未接受该药物治疗的15名患者组成的对照组中,病变未出现明显变化。氨苯砜因此首次被成功使用。