Miltner Wolfgang, Johnson Ray, Braun Christoph, Larbig Wolfgang
Department of Medical Psychology, University of Tübingen, 7400 TübingenF.R.G. Cognitive Neuroscience Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 U.S.A. Department of Psychology, University of Tubingen, 7400 TübingenF.R.G.
Pain. 1989 Sep;38(3):303-312. doi: 10.1016/0304-3959(89)90217-0.
In order to determine the effects of attention and distraction on painful and non-painful stimuli, the amplitude changes of 3 components (N150, P200, P300) of the somatosensory event-related potential (SERP) elicited by painful and non-painful electrical stimuli were investigated. Painful and non-painful stimuli were determined using a visual analog scale. SERPs were recorded from 16 healthy volunteers at 5 midline and 4 left and 4 right hemispheric sites. The differences between the amplitudes of attended and ignored stimuli were quantified with a baseline-to-peak measure. ANOVA results revealed no significant attention or stimulus intensity effects for N150 but highly significant differences in P200 and P300 amplitudes between attended and ignored stimuli. In addition, P200 and P300 amplitudes were larger for strong stimuli than for weak stimuli, with no significant differences between non-painful and painful stimuli. These findings are consistent with the existence of a relative, rather than an absolute, relationship between SERP component amplitudes and subjective pain reports. Furthermore, the data give evidence that attentional manipulations represent a powerful method to decrease the perception of pain and that, when used with subjective and behavioral measures, the SERP represents a valuable asset in the multidimensional approach to pain measurement and assessment.
为了确定注意力和分心对疼痛和非疼痛刺激的影响，研究了由疼痛和非疼痛电刺激诱发的体感事件相关电位（SERP）的3个成分（N150、P200、P300）的幅度变化。使用视觉模拟量表确定疼痛和非疼痛刺激。从16名健康志愿者的5个中线部位以及4个左侧和4个右侧半球部位记录SERP。采用基线到峰值测量法对被关注刺激和被忽略刺激的幅度差异进行量化。方差分析结果显示，N150不存在显著的注意力或刺激强度效应，但被关注刺激和被忽略刺激的P200和P300幅度存在高度显著差异。此外，强刺激的P200和P300幅度大于弱刺激，非疼痛刺激和疼痛刺激之间无显著差异。这些发现与SERP成分幅度和主观疼痛报告之间存在相对而非绝对的关系这一观点一致。此外，数据表明注意力操纵是一种减轻疼痛感知的有效方法，并且当与主观和行为测量方法结合使用时，SERP是疼痛测量和评估多维方法中的一项宝贵资产。
