• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

从样本中识别概率布尔阈值网络。

Identifying a Probabilistic Boolean Threshold Network From Samples.

出版信息

IEEE Trans Neural Netw Learn Syst. 2018 Apr;29(4):869-881. doi: 10.1109/TNNLS.2017.2648039. Epub 2017 Jan 25.

DOI:10.1109/TNNLS.2017.2648039
PMID:28129190
Abstract

This paper studies the problem of exactly identifying the structure of a probabilistic Boolean network (PBN) from a given set of samples, where PBNs are probabilistic extensions of Boolean networks. Cheng et al. studied the problem while focusing on PBNs consisting of pairs of AND/OR functions. This paper considers PBNs consisting of Boolean threshold functions while focusing on those threshold functions that have unit coefficients. The treatment of Boolean threshold functions, and triplets and -tuplets of such functions, necessitates a deepening of the theoretical analyses. It is shown that wide classes of PBNs with such threshold functions can be exactly identified from samples under reasonable constraints, which include: 1) PBNs in which any number of threshold functions can be assigned provided that all have the same number of input variables and 2) PBNs consisting of pairs of threshold functions with different numbers of input variables. It is also shown that the problem of deciding the equivalence of two Boolean threshold functions is solvable in pseudopolynomial time but remains co-NP complete.

摘要

本文研究了从给定样本集中准确识别概率布尔网络(PBN)结构的问题,其中 PBN 是布尔网络的概率扩展。Cheng 等人在研究该问题时,重点关注由 AND/OR 函数对组成的 PBN。本文考虑了由布尔门限函数组成的 PBN,重点关注那些系数为 1 的门限函数。布尔门限函数以及此类函数的三元组和四元组的处理需要深化理论分析。结果表明,在合理的约束下,可以从样本中准确识别具有此类门限函数的广泛类别的 PBN,其中包括:1)可以分配任意数量的门限函数,只要它们具有相同数量的输入变量,以及 2)由具有不同数量输入变量的门限函数对组成的 PBN。此外,还表明判断两个布尔门限函数是否等价的问题可以在伪多项式时间内解决,但仍然属于 co-NP 完全问题。

相似文献

1
Identifying a Probabilistic Boolean Threshold Network From Samples.从样本中识别概率布尔阈值网络。
IEEE Trans Neural Netw Learn Syst. 2018 Apr;29(4):869-881. doi: 10.1109/TNNLS.2017.2648039. Epub 2017 Jan 25.
2
Identification of the Structure of a Probabilistic Boolean Network From Samples Including Frequencies of Outcomes.从包含结果频率的样本中识别概率布尔网络的结构。
IEEE Trans Neural Netw Learn Syst. 2019 Aug;30(8):2383-2396. doi: 10.1109/TNNLS.2018.2884454. Epub 2018 Dec 24.
3
Exact Identification of the Structure of a Probabilistic Boolean Network from Samples.从样本中精确识别概率布尔网络的结构
IEEE/ACM Trans Comput Biol Bioinform. 2016 Nov-Dec;13(6):1107-1116. doi: 10.1109/TCBB.2015.2505310. Epub 2015 Dec 3.
4
Intervention in context-sensitive probabilistic Boolean networks.上下文敏感概率布尔网络中的干预
Bioinformatics. 2005 Apr 1;21(7):1211-8. doi: 10.1093/bioinformatics/bti131. Epub 2004 Nov 5.
5
Design of Probabilistic Boolean Networks Based on Network Structure and Steady-State Probabilities.基于网络结构和稳态概率的概率布尔网络设计。
IEEE Trans Neural Netw Learn Syst. 2017 Aug;28(8):1966-1971. doi: 10.1109/TNNLS.2016.2572063. Epub 2016 Jun 6.
6
The complex fluctuations of probabilistic Boolean networks.概率布尔网络的复杂波动
Biosystems. 2013 Oct;114(1):78-84. doi: 10.1016/j.biosystems.2013.07.008. Epub 2013 Jul 16.
7
Stochastic Boolean networks: an efficient approach to modeling gene regulatory networks.随机布尔网络:一种建模基因调控网络的有效方法。
BMC Syst Biol. 2012 Aug 28;6:113. doi: 10.1186/1752-0509-6-113.
8
ASSA-PBN: A Toolbox for Probabilistic Boolean Networks.ASSA-PBN:概率布尔网络工具包。
IEEE/ACM Trans Comput Biol Bioinform. 2018 Jul-Aug;15(4):1203-1216. doi: 10.1109/TCBB.2017.2773477. Epub 2017 Nov 14.
9
Synchronization for the Realization-Dependent Probabilistic Boolean Networks.基于实现的概率布尔网络的同步化。
IEEE Trans Neural Netw Learn Syst. 2018 Apr;29(4):819-831. doi: 10.1109/TNNLS.2017.2647989. Epub 2017 Jan 24.
10
Distribution and enumeration of attractors in probabilistic Boolean networks.概率布尔网络中的吸引子分布与计数。
IET Syst Biol. 2009 Nov;3(6):465-74. doi: 10.1049/iet-syb.2008.0177.

引用本文的文献

1
LogBTF: gene regulatory network inference using Boolean threshold network model from single-cell gene expression data.LogBTF:基于单细胞基因表达数据的布尔阈值网络模型进行基因调控网络推断。
Bioinformatics. 2023 May 4;39(5). doi: 10.1093/bioinformatics/btad256.
2
Discovering gene regulatory networks of multiple phenotypic groups using dynamic Bayesian networks.利用动态贝叶斯网络发现多个表型组的基因调控网络。
Brief Bioinform. 2022 Jul 18;23(4). doi: 10.1093/bib/bbac219.