Department of Endocrinology, Austin Health, Melbourne, Victoria, Australia.
Department of Medicine, Austin Health, The University of Melbourne, Melbourne, Victoria, Australia.
J Diabetes Investig. 2017 Sep;8(5):697-700. doi: 10.1111/jdi.12634. Epub 2017 Mar 23.
It is unknown if high prolactin levels during pregnancy contribute to the development of gestational diabetes. We hypothesized that higher prolactin levels are associated with reduced glucose tolerance, as determined by higher 2-h glucose level from an oral glucose tolerance test in pregnancy. The 75-g oral glucose tolerance test was carried out at 28 weeks of gestation in 69 participants. A multiple regression analysis was used to determine the relationship between serum prolactin and 2-h glucose levels. Multivariable regression analysis showed an independent and significant relationship between third trimester prolactin and 2-h glucose levels post oral glucose tolerance test. Higher prolactin levels were associated with higher glucose levels independent of age, body mass index, gravidity and parity. Higher prolactin levels associated with reduced glucose tolerance in the third trimester of pregnancy suggests the possible independent role of prolactin in the pathogenesis of gestational diabetes.
尚不清楚怀孕期间催乳素水平升高是否会导致妊娠糖尿病的发生。我们假设催乳素水平升高与葡萄糖耐量降低有关，这可以通过在妊娠期间口服葡萄糖耐量试验中更高的 2 小时血糖水平来确定。在 69 名参与者中，于妊娠 28 周时进行了 75g 口服葡萄糖耐量试验。采用多元回归分析来确定血清催乳素与 2 小时血糖水平之间的关系。多变量回归分析显示，妊娠晚期催乳素与口服葡萄糖耐量试验后 2 小时血糖水平之间存在独立且显著的关系。催乳素水平较高与葡萄糖水平升高有关，与年龄、体重指数、孕次和产次无关。妊娠晚期催乳素水平升高与葡萄糖耐量降低有关，这提示催乳素可能在妊娠糖尿病的发病机制中起独立作用。
