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本文引用的文献

1
Pan-cancer Immunogenomic Analyses Reveal Genotype-Immunophenotype Relationships and Predictors of Response to Checkpoint Blockade.泛癌免疫基因组分析揭示基因型-免疫表型关系和预测免疫检查点阻断反应的标志物。
Cell Rep. 2017 Jan 3;18(1):248-262. doi: 10.1016/j.celrep.2016.12.019.
2
Transcriptional Landscape of Human Tissue Lymphocytes Unveils Uniqueness of Tumor-Infiltrating T Regulatory Cells.人类组织淋巴细胞的转录图谱揭示了肿瘤浸润性调节性T细胞的独特性。
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Regulatory T Cells Exhibit Distinct Features in Human Breast Cancer.调节性T细胞在人类乳腺癌中表现出不同特征。
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Computational genomics tools for dissecting tumour-immune cell interactions.计算基因组学工具可用于剖析肿瘤-免疫细胞相互作用。
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5
Two FOXP3(+)CD4(+) T cell subpopulations distinctly control the prognosis of colorectal cancers.两种 FOXP3(+)CD4(+) T 细胞亚群可明显控制结直肠癌的预后。
Nat Med. 2016 Jun;22(6):679-84. doi: 10.1038/nm.4086. Epub 2016 Apr 25.
6
Characterization of the immunophenotypes and antigenomes of colorectal cancers reveals distinct tumor escape mechanisms and novel targets for immunotherapy.结直肠癌免疫表型和抗原组的特征揭示了独特的肿瘤逃逸机制和免疫治疗新靶点。
Genome Biol. 2015 Mar 31;16(1):64. doi: 10.1186/s13059-015-0620-6.
7
The blockade of immune checkpoints in cancer immunotherapy.癌症免疫疗法中的免疫检查点阻断。
Nat Rev Cancer. 2012 Mar 22;12(4):252-64. doi: 10.1038/nrc3239.
8
The immune contexture in human tumours: impact on clinical outcome.人类肿瘤中的免疫结构：对临床结果的影响。
Nat Rev Cancer. 2012 Mar 15;12(4):298-306. doi: 10.1038/nrc3245.

癌症免疫疗法的新策略：靶向调节性T细胞。

New strategies for cancer immunotherapy: targeting regulatory T cells.

作者信息

Finotello Francesca, Trajanoski Zlatko

机构信息

Biocenter, Division of Bioinformatics, Medical University of Innsbruck, Innsbruck, 6020, Austria.

出版信息

Genome Med. 2017 Jan 27;9(1):10. doi: 10.1186/s13073-017-0402-8.

DOI:10.1186/s13073-017-0402-8
PMID:28129791
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5273791/
Abstract

The immunosuppressive action of regulatory T (T) cells is one mechanism attributed to the limited success of cancer immunotherapies with checkpoint blockers. Two recent studies report distinct transcriptional profiles of tumor-infiltrating T cells and expression of specific molecules, suggesting novel strategies to overcome resistance to cancer immunotherapy.

摘要

调节性T（Treg）细胞的免疫抑制作用是检查点阻断癌症免疫疗法取得有限成功的一种机制。最近的两项研究报告了肿瘤浸润性T细胞的不同转录谱和特定分子的表达，提示了克服癌症免疫治疗耐药性的新策略。