Abduljabbar Tariq, Al-Askar Mansour, Baig Mohammed K, AlSowygh Zeyad H, Kellesarian Sergio Varela, Vohra Fahim
Department of Prosthetic Dental Sciences, College of Dentistry, King Saud University, Riyadh, Saudi Arabia.
Department of Periodontics and Community Dentistry, King Saud University, Riyadh, Saudi Arabia.
Photodiagnosis Photodyn Ther. 2017 Jun;18:50-53. doi: 10.1016/j.pdpdt.2017.01.182. Epub 2017 Jan 24.
The aim was to assess the efficacy of antimicrobial photodynamic therapy (aPDT) in the inactivation of oral fungal colonization among cigarette smokers and non-smokers with denture stomatitis (DS).
A questionnaire was used to gather demographic information. Clinical oral examination was performed to determine location of denture in the jaws and oral erythematous lesions. Presence of fungal hyphae in smokers and non-smokers was confirmed using exfoliative cytology. In both groups, aPDT was performed and colony forming units per milliliter (CFU/ml) were assessed im both groups at 3-months follow-up. Level of significance was et at P<0.05.
Twenty-two males with DS (12 smokers and 10 non-smokers) were included. The mean ages of smokers and non-smokers was 73.8±2.5 and 70.5±1.2years, respectively. The duration and daily frequency of cigarette smoking was 20.6±4.5years and 12.3±1.5 cigarettes daily, respectively. Smokers and non-smokers had been wearing complete dentures since 6.2±0.8 and 5.8±0.4years, respectively. At 3-months follow-up, there was a statistically significant decrease in the mean fungal CFU/ml among smokers (25.5±8.3 CFU/ml) compared with their respective baseline values 106.7±6.3 CFU/ml (P<0.01). Among non-smokers, the mean CFU/ml values were 12.7±0.8 CFU/ml compared with their respective baseline values (93.6±8.4 CFU/ml) (P<0.01). At 3-months follow-up, fungal CFU/ml levels were statistically significantly higher among smokers (25.5±8.3 CFU/ml) compared with non-smokers (12.7±0.8 CFU/ml) (P<0.05).
aPDT is effective in the inactivation of oral fungal colonization among cigarette smokers and non-smokers with. The role of denture is also emphasized.
评估抗菌光动力疗法（aPDT）对患有义齿性口炎（DS）的吸烟者和非吸烟者口腔真菌定植的灭活效果。
使用问卷收集人口统计学信息。进行临床口腔检查以确定义齿在颌骨中的位置和口腔红斑病变。通过脱落细胞学检查确认吸烟者和非吸烟者中真菌菌丝的存在。在两组中均进行了aPDT，并在3个月随访时评估两组每毫升的菌落形成单位（CFU/ml）。显著性水平设定为P<0.05。
纳入了22名患有DS的男性（12名吸烟者和10名非吸烟者）。吸烟者和非吸烟者的平均年龄分别为73.8±2.5岁和70.5±1.2岁。吸烟的持续时间和每日吸烟量分别为20.6±4.5年和每日12.3±1.5支香烟。吸烟者和非吸烟者分别已佩戴全口义齿6.2±0.8年和5.8±0.4年。在3个月随访时，与各自的基线值106.7±6.3 CFU/ml相比，吸烟者的平均真菌CFU/ml有统计学显著下降（25.5±8.3 CFU/ml）（P<0.01）。在非吸烟者中，平均CFU/ml值为12.7±0.8 CFU/ml，与各自的基线值（93.6±8.4 CFU/ml）相比（P<0.01）。在3个月随访时，吸烟者的真菌CFU/ml水平（25.5±8.3 CFU/ml）与非吸烟者（12.7±0.8 CFU/ml）相比有统计学显著升高（P<0.05）。
aPDT对患有义齿性口炎的吸烟者和非吸烟者的口腔真菌定植灭活有效。同时强调了义齿的作用。
