通过“过滤”方法合成环状寡脱氧核糖核苷酸。
Synthesis of cyclic oligodeoxyribonucleotides via the 'filtration' approach.
作者信息
Rao M V, Reese C B
机构信息
Department of Chemistry, King's College London, Strand, UK.
出版信息
Nucleic Acids Res. 1989 Oct 25;17(20):8221-39. doi: 10.1093/nar/17.20.8221.
Abstract
The synthesis of cyclic di-, tri-, tetra-, penta- and hexa-thymidylic acids (16; n = 2, 3, 4, 5 and 6) and the cyclic hexadeoxyribonucleotide [d(CpCpTpApGpGp)], via the "filtration" approach, is reported. Some of the physical properties of the cyclic oligonucleotides are discussed, and their susceptibility to digestion in the presence of phosphorylytic enzymes has been studied.
摘要
报道了通过“过滤”方法合成环状二聚、三聚、四聚、五聚和六聚胸苷酸（16；n = 2、3、4、5和6）以及环状十六脱氧核糖核苷酸[d(CpCpTpApGpGp)]。讨论了环状寡核苷酸的一些物理性质，并研究了它们在磷酸解酶存在下的消化敏感性。
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本文引用的文献
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