Orthopaedic Biomechanics, Department of Biomedical Engineering, Eindhoven University of Technology, PO Box 513, 5600 MB Eindhoven, The Netherlands; Institute for Complex Molecular Systems, Eindhoven University of Technology, PO Box 513, 5600 MB Eindhoven, The Netherlands.
Department of Orthopaedic Surgery, Research School CAPHRI, Maastricht University Medical Centre, PO Box 5800, 6229 HX Maastricht, The Netherlands; MICT Department, Jeroen Bosch Ziekenhuis, PO Box 90153, 5200 ME 's-Hertogenbosch, The Netherlands.
J Mech Behav Biomed Mater. 2017 May;69:301-306. doi: 10.1016/j.jmbbm.2017.01.024. Epub 2017 Jan 18.
To improve the handling properties of S53P4 bioactive glass granules for clinical applications, bioactive glass putty formulations were developed. These formulations contain both granules and a synthetic binder to form an injectable material that is easy to shape. To explore its applicability in load-bearing bone defect grafting, the relation between the putty composition and its mechanical behaviour was assessed in this study. Five putty formulations with variations in synthetic binder and granule content were mechanically tested in confined compression. The results showed that the impaction strains significantly decreased and the residual strains significantly increased with an increasing binder content. The stiffness of all tested formulations was found to be in the same range as the reported stiffness of cancellous bone. The measured creep strains were low and no significant differences between formulations were observed. The stiffness significantly increased when the samples were subjected to a second loading stage. The residual strains calculated from this second loading stage were also significantly different from the first loading stage, showing an increasing difference with an increasing binder content. Since residual strains are detrimental for graft layer stability in load-bearing defects, putty compositions with a low binder content would be most beneficial for confined, load-bearing bone defect grafting.
为改善 S53P4 生物活性玻璃颗粒的处理性能，用于临床应用，开发了生物活性玻璃腻子配方。这些配方既含有颗粒又含有合成粘合剂，可形成易于成型的可注射材料。为了探索其在承重骨缺损植骨中的适用性，本研究评估了腻子配方与其机械性能之间的关系。对五种具有不同合成粘合剂和颗粒含量的腻子配方进行了约束压缩下的力学性能测试。结果表明，随着粘合剂含量的增加，冲击应变显著减小，残余应变显著增加。所有测试配方的刚度均与报道的松质骨刚度处于同一范围内。测量的蠕变应变较低，各配方之间没有明显差异。当样品经受第二加载阶段时，刚度显著增加。从第二加载阶段计算出的残余应变也与第一加载阶段明显不同，随着粘合剂含量的增加，差异逐渐增大。由于残余应变对承重缺陷中移植物层的稳定性不利，因此具有低粘合剂含量的腻子配方最有利于约束、承重骨缺损植骨。
