Miller Maria
Protein Structure Section, Macromolecular Crystallography Laboratory, National Cancer Institute at Frederick, Frederick, MD, 21702-1201, USA.
Postepy Biochem. 2016;62(3):343-348.
CCAAT/enhancer-binding proteins (C/EBPs) are key regulators of numerous cellular processes, including cell proliferation, differentiation, and tumorigenesis. Their biological activities require interactions with several protein partners and the formation of functional multiprotein complexes involved in DNA repair and cell cycle control. Members of the family (C/EBPα, β, δ, ε, and γ) bind to common DNA sequence motifs as homo- or hetero-dimers and interact with other transcription factors to control transcription of a number of eukaryotic genes. Of particular interest is C/EBPβ, which binds to closed chromatin and acts as a pioneering factor for initiating tissue-specific gene expression at several promoters. This review focuses on intermolecular interactions that underlie C/EBPβ's ability to regulate chromatin accessibility and directs readers to general reviews describing transcription regulation in eukaryotes.
CCAAT/增强子结合蛋白（C/EBPs）是众多细胞过程的关键调节因子，包括细胞增殖、分化和肿瘤发生。它们的生物学活性需要与多个蛋白质伙伴相互作用，并形成参与DNA修复和细胞周期控制的功能性多蛋白复合物。该家族成员（C/EBPα、β、δ、ε和γ）以同二聚体或异二聚体形式结合共同的DNA序列基序，并与其他转录因子相互作用，以控制许多真核基因的转录。特别值得关注的是C/EBPβ，它与封闭染色质结合，并作为先驱因子在多个启动子处启动组织特异性基因表达。本综述重点关注C/EBPβ调节染色质可及性能力背后的分子间相互作用，并引导读者阅读描述真核生物转录调控的一般性综述。
