Corbo M, Liu J C, Chien Y W
Controlled Drug-Delivery Research Center, Rutgers University College of Pharmacy, Piscataway, New Jersey 08855-0789.
Pharm Res. 1989 Sep;6(9):753-8. doi: 10.1023/a:1015967329033.
The feasibility of transdermal controlled delivery of propranolol was investigated by conducting in vitro skin permeation studies using rabbit pinna (ear) skin. A new multilaminate adhesive device which is capable of releasing propranolol in a controlled fashion over a 24-hr period had been developed and was evaluated transdermally using rabbit pinna skin. Skin permeation of propranolol from the device was found to be controlled by the stratum corneum during the early phase of permeation and then by the adhesive device during steady-state permeation. The rabbit pinna skin was shown to be a good animal model for studying the transdermal permeation of propranolol from the device, when compared to human cadaver skin.
通过使用兔耳廓（耳朵）皮肤进行体外皮肤渗透研究，考察了普萘洛尔经皮控释的可行性。已开发出一种新型多层粘贴装置，该装置能够在24小时内以可控方式释放普萘洛尔，并使用兔耳廓皮肤对其进行了经皮评价。研究发现，在渗透早期，普萘洛尔从该装置的皮肤渗透受角质层控制，而在稳态渗透期间则受粘贴装置控制。与人类尸体皮肤相比，兔耳廓皮肤被证明是研究普萘洛尔从该装置经皮渗透的良好动物模型。
