脑室内注射牛磺酸、γ-氨基丁酸和高牛磺酸对雄性大鼠血清催乳素水平影响的比较。

Comparison of the effects of intraventricular taurine, GABA and homotaurine on serum prolactin levels in male rats.

作者信息

Panula-Lehto E, Ahtee L, Tuominen R K, Männistö P T

机构信息

Department of Pharmacy, University of Helsinki, Finland.

出版信息

Pharmacol Toxicol. 1989 Aug;65(2):152-6. doi: 10.1111/j.1600-0773.1989.tb01146.x.

DOI:10.1111/j.1600-0773.1989.tb01146.x

PMID:2813286

Abstract

The effects of taurine (2-aminoethanesulphonic acid), gamma-aminobutyric acid (GABA) and homotaurine (3-aminopropanesulphonic acid), a structural analogue of both taurine and GABA, on serum prolactin (PRL) levels were compared in conscious, unrestrained male rats. Taurine, injected into the lateral brain ventricles at doses of 6 and 10 mumol per rat, elevated serum PRL level by 52% (P less than 0.01) and 90% (P less than 0.001), respectively. GABA elevated serum PRL level (41%, P less than 0.05) only at the lowest dose (1 mumol) tested. Homotaurine was the most effective compound, eliciting increases of 353% and 449% (P less than 0.001) at 6 and 10 mumol per rat, respectively. The rank order of the three amino acids in elevating serum PRL level bears some similarity to their known rank order of potency in altering cerebral dopamine metabolism.

摘要

在清醒、无束缚的雄性大鼠中，比较了牛磺酸（2-氨基乙磺酸）、γ-氨基丁酸（GABA）和高牛磺酸（3-氨基丙烷磺酸，牛磺酸和GABA的结构类似物）对血清催乳素（PRL）水平的影响。以每只大鼠6和10 μmol的剂量将牛磺酸注入侧脑室，血清PRL水平分别升高了52%（P<0.01）和90%（P<0.001）。GABA仅在测试的最低剂量（1 μmol）时升高了血清PRL水平（41%，P<0.05）。高牛磺酸是最有效的化合物，每只大鼠6和10 μmol时分别引起353%和449%的升高（P<0.001）。这三种氨基酸在升高血清PRL水平方面的排序顺序与它们在改变脑多巴胺代谢方面已知的效力排序顺序有一些相似之处。