Assessment of Serum Vascular Endothelial Growth Factor Levels in Pregnancy-Induced Hypertension Patients.

. The objective of the study was to assess the serum vascular endothelial growth factor (VEGF) levels in peripheral blood of patients with pregnancy-induced hypertension (PIH) and find association between serum VEGF levels and PIH. . Thirty-five PIH subjects, 35 normal pregnant females, and 20 normal healthy females were included in the study. Detailed history, clinical examination, and relevant biochemical parameters were assessed; serum VEGF levels were estimated using Double-antibody enzyme-linked immunosorbent assay. . The study groups were found to be age matched ( = 0.38). VEGF level in the pregnancy-induced hypertensive group (median = 109.19 (3.38 ± 619)) was significantly higher than the normal pregnant (median = 20.82 (1.7-619)) and control (median = 4.92 (1.13-13.07)) group and the difference between these three groups was significant ( < 0.0001). The 3 groups are found to be significantly different in terms of RBS ( = 0.01), urea ( < 0.0001), creatinine ( = 0.0005), AST ( = 0.0032), ALT ( = 0.0007), total protein ( = 0.0004), albumin ( < 0.0001), calcium ( = 0.001), and sodium ( = 0.02), while no statistically significant difference was found between total bilirubin ( = 0.167), direct bilirubin ( = 0.07), uric acid ( = 0.16), and potassium ( = 0.14). . Significantly higher levels of serum VEGF were noted in PIH subjects compared to normal pregnant and control subjects.