Nuclear Organization and Oncogenesis Unit, INSERM U993, Institut Pasteur, 28 rue de Dr Roux, 75724 Paris Cedex 15, France.
Nat Rev Cancer. 2017 Mar;17(3):184-197. doi: 10.1038/nrc.2016.143. Epub 2017 Jan 30.
Post-translational protein modification by small ubiquitin-like modifier (SUMO), termed sumoylation, is an important mechanism in cellular responses to stress and one that appears to be upregulated in many cancers. Here, we examine the role of sumoylation in tumorigenesis as a possibly necessary safeguard that protects the stability and functionality of otherwise easily misregulated gene expression programmes and signalling pathways of cancer cells.
蛋白质翻译后修饰的小泛素相关修饰物（SUMO），即 SUMO 化，是细胞对压力做出反应的一个重要机制，并且似乎在许多癌症中上调。在这里，我们研究 SUMO 化在肿瘤发生中的作用，因为它可能是一种必要的保护措施，可以保护癌细胞中不稳定和易调控的基因表达程序和信号通路的稳定性和功能。
