Bernadt Cory T, Collins Brian T
Department of Pathology and Immunology, Washington University in St. Louis School of Medicine, St. Louis, Missouri, USA.
Diagn Cytopathol. 2017 Mar;45(3):221-229. doi: 10.1002/dc.23668. Epub 2017 Jan 30.
Human papillomavirus (HPV)-related head and neck squamous cell carcinoma (HNSCC) is a unique form of carcinoma that largely arises from the tonsillar tissue in the oropharynx. These tumors often present with cervical lymphadenopathy resulting in a fine needle aspiration (FNA) biopsy. Use of the cytology specimen to determine the HPV-status has significant prognostic and treatment implications as HPV-related tumors have a more favorable prognosis and response to nonsurgical therapies. While several different ancillary testing methods are available that have proven effective for determining HPV status in FNA specimens from HNSCCs, there is currently no consensus regarding HPV testing in this setting. Diagn. Cytopathol. 2017;45:221-229. © 2016 Wiley Periodicals, Inc.
人乳头瘤病毒（HPV）相关的头颈部鳞状细胞癌（HNSCC）是一种独特的癌症形式，主要起源于口咽的扁桃体组织。这些肿瘤常伴有颈部淋巴结病，从而导致细针穿刺抽吸（FNA）活检。由于HPV相关肿瘤具有更良好的预后以及对非手术治疗的反应，利用细胞学标本确定HPV状态具有重要的预后和治疗意义。虽然有几种不同的辅助检测方法已被证明可有效确定HNSCC的FNA标本中的HPV状态，但目前在这种情况下HPV检测尚无共识。《诊断细胞病理学》2017年；45卷：221 - 229页。©2016威利期刊公司
