Walker M A, Harley R A, DeLustro F A, LeRoy E C
Department of Medicine, Medical University of South Carolina, Charleston 29425.
Proc Soc Exp Biol Med. 1989 Nov;192(2):196-200. doi: 10.3181/00379727-192-42979.
The tight skin mouse (Tsk/+) is an autosomal dominant example of inherited fibrosis whose pathogenesis is unclear. Autoimmune phenomena have been described previously. This study demonstrates the adoptive transfer of skin fibrosis to lethally irradiated syngeneic +/+ recipients by the transplantation of both bone marrow and spleen cells. The recipient skin fibrosis was not associated with mast cell proliferation or degranulation as it is in the tsk/+ mouse, representing for the first time a dissociation between mast cells and fibrosis and introducing the potential for direct T cell-fibroblast interactions.
紧皮小鼠（Tsk/+）是遗传性纤维化的常染色体显性遗传实例，其发病机制尚不清楚。先前已有自身免疫现象的描述。本研究证明，通过移植骨髓和脾细胞，可将皮肤纤维化过继转移至接受致死性照射的同基因+/+受体小鼠。受体小鼠的皮肤纤维化与tsk/+小鼠不同，不伴有肥大细胞增殖或脱颗粒，这首次表明肥大细胞与纤维化之间存在分离，并提示了T细胞与成纤维细胞直接相互作用的可能性。
