Smith Maxwell L
Arch Pathol Lab Med. 2017 Feb;141(2):223-231. doi: 10.5858/arpa.2016-0098-RA.
-Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis commonly presents with pulmonary and renal involvement that may present diagnostic challenges.
-To highlight the updates in the classification of small vessel vasculitis, present the patterns of pulmonary and renal pathology in which ANCA-associated vasculitis is included in the differential diagnosis, analyze the screening and specific antineutrophil cytoplasmic antibody testing methods in the clinical laboratory, compare and contrast the 3 major ANCA-associated vasculitis diseases, and review the pathophysiologic mechanisms of tissue injury in this setting.
-Data are derived from published literature and clinical experience.
-Although rare, ANCA-associated vasculitis diseases are often considered in the differential diagnosis of many pathologic patterns of pulmonary and renal disease. Histopathologic diagnosis of specific entities in this context nearly always requires correlation of the pathology with clinical and serologic data.
抗中性粒细胞胞浆抗体（ANCA）相关血管炎通常表现为肺部和肾脏受累，这可能带来诊断挑战。
强调小血管炎分类的更新，呈现抗中性粒细胞胞浆抗体相关血管炎鉴别诊断中所包含的肺部和肾脏病理模式，分析临床实验室中的筛查及特异性抗中性粒细胞胞浆抗体检测方法，比较并对比3种主要的抗中性粒细胞胞浆抗体相关血管炎疾病，并回顾此情况下组织损伤的病理生理机制。
数据源自已发表文献及临床经验。
尽管罕见，但在许多肺部和肾脏疾病的病理模式鉴别诊断中，常需考虑抗中性粒细胞胞浆抗体相关血管炎疾病。在此背景下，特定实体的组织病理学诊断几乎总是需要将病理与临床和血清学数据相关联。
