Stozek T, Krówczyński L
Lehrstuhl für Pharmazeutische Technologie und Biopharmazie, Medizinischen Akademie Kraków, VR Polen.
Pharmazie. 1989 Jul;44(7):466-8.
The study has shown the effect of liposomally entrapped procaine hydrochloride on local anaesthesia and its intensity after intradermal administration. The experiments of anaesthetic infiltration have been carried out on guinea pig skin applying mechanical stimulus. Liposomes were prepared by the shaking method followed by suspending in phosphate buffer pH 7.2, 0.5% methylcellulose in phosphate buffer or 5% glucose solution. The results of the study were compared with those of procaine hydrochloride in analogous solutions. The study has shown significant influence of liposomally entrapped procaine hydrochloride on the prolongation of local anaesthesia and its intensity. It has also been shown that local anaesthesia was influenced by the composition of the solutions in which liposomes were suspended. The longest effect (55 min) has been observed after administration of liposomes in phosphate buffer with methylcellulose.
该研究显示了脂质体包裹的盐酸普鲁卡因对局部麻醉的效果及其皮内给药后的强度。应用机械刺激在豚鼠皮肤上进行了麻醉浸润实验。通过振荡法制备脂质体，然后将其悬浮于pH 7.2的磷酸盐缓冲液、磷酸盐缓冲液中的0.5%甲基纤维素或5%葡萄糖溶液中。将该研究结果与类似溶液中盐酸普鲁卡因的结果进行了比较。该研究表明，脂质体包裹的盐酸普鲁卡因对局部麻醉的延长及其强度有显著影响。还表明局部麻醉受脂质体悬浮其中的溶液组成的影响。在含有甲基纤维素的磷酸盐缓冲液中给予脂质体后观察到最长效果（55分钟）。
