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儿童和青少年的急性应激障碍及向创伤后应激障碍的转变:患病率、病程、预后、诊断适用性及风险标志物

Acute stress disorder and the transition to posttraumatic stress disorder in children and adolescents: Prevalence, course, prognosis, diagnostic suitability, and risk markers.

作者信息

Meiser-Stedman Richard, McKinnon Anna, Dixon Clare, Boyle Adrian, Smith Patrick, Dalgleish Tim

机构信息

Medical Research Council Cognition and Brain Sciences Unit, Cambridge.

Department of Clinical Psychology, University of East Anglia, Norwich, UK.

出版信息

Depress Anxiety. 2017 Apr;34(4):348-355. doi: 10.1002/da.22602. Epub 2017 Jan 30.

Abstract

BACKGROUND

Early recovery from trauma exposure in youth is poorly understood. This prospective longitudinal study examined the early course of traumatic stress responses in recently trauma-exposed youth, evaluated the revised DSM-5 acute stress disorder (ASD) and PTSD diagnoses and alternative diagnoses, and identified risk factors for persistent traumatic stress.

METHOD

Participants were 8- to 17-year-old emergency departments attendees exposed to single incident traumas. Structured clinical interviews were undertaken at 2 (n = 226) and 9 weeks (n = 208) posttrauma.

RESULTS

Using the revised criteria in DSM-5, 14.2% met criteria for ASD at week 2 and 9.6% met criteria for PTSD at week 9. These prevalences were similar to the corresponding DSM-IV diagnoses (18.6% ASD at week 2; 8.7% PTSD at week 9). Using the same diagnostic criteria (DSM-IV or DSM-5) across assessments (i.e., "2-week PTSD") suggested that caseness declined in prevalence by approximately half. Overlap between DSM-IV and DSM-5 ASD and DSM-5 preschool child PTSD diagnoses was considerable. Two diagnoses were strongly predictive of corresponding week 9 diagnoses. Youth with ASD who subsequently had PTSD reported more negative alterations in cognition and mood at 2 weeks than those youth who did not develop PTSD.

CONCLUSIONS

Youth exposed to single-event traumas experience considerable natural recovery in the first months posttrauma. Using DSM-5 criteria, ASD may not capture all clinically significant traumatic stress in the acute phase and is only moderately sensitive for later PTSD. Future research needs to address the role and etiology of negative alterations in cognition and mood symptoms.

摘要

背景

青少年创伤暴露后的早期恢复情况鲜为人知。这项前瞻性纵向研究考察了近期遭受创伤的青少年创伤应激反应的早期过程,评估了修订后的《精神疾病诊断与统计手册》第五版(DSM-5)急性应激障碍(ASD)和创伤后应激障碍(PTSD)的诊断及替代诊断,并确定了持续性创伤应激的风险因素。

方法

参与者为8至17岁因单次事件创伤而到急诊科就诊的患者。在创伤后2周(n = 226)和9周(n = 208)进行结构化临床访谈。

结果

根据DSM-5的修订标准,第2周时14.2%符合ASD标准,第9周时9.6%符合PTSD标准。这些患病率与相应的DSM-IV诊断相似(第2周时ASD为18.6%;第9周时PTSD为8.7%)。在各次评估中使用相同的诊断标准(DSM-IV或DSM-5)(即“2周PTSD”)表明,病例患病率下降了约一半。DSM-IV和DSM-5的ASD以及DSM-5学龄前儿童PTSD诊断之间的重叠相当大。两种诊断对第9周的相应诊断有很强的预测性。随后患PTSD的ASD青少年在2周时报告的认知和情绪负面变化比未患PTSD的青少年更多。

结论

遭受单次事件创伤的青少年在创伤后的头几个月会经历相当程度的自然恢复。根据DSM-5标准,ASD可能无法涵盖急性期所有具有临床意义的创伤应激,且对后期PTSD的敏感性仅为中等。未来的研究需要探讨认知和情绪症状负面变化的作用及病因。

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