Hikino H, Yoshizawa M, Suzuki Y, Oshima Y, Konno C
Planta Med. 1989 Aug;55(4):349-50. doi: 10.1055/s-2006-962025.
The non-dialyzable portion of the water extract of the Oriental crude drug "karokon", the roots of Trichosanthes kirilowii, was found to reduce the plasma glucose level in mice. Activity-guided fractionation of this non-dialyzable portion led to the isolation of five glycans termed as trichosans A, B, C, D and E, showing hypoglycemic actions in normal mice. The main glycan, trichosan A, also exhibited activity in alloxan-induced hyperglycemic mice.
东方生药“栝楼根”（即瓜蒌 Trichosanthes kirilowii 的根）水提取物的非透析部分被发现可降低小鼠的血糖水平。对该非透析部分进行活性导向分离，得到了五种聚糖，分别命名为天花粉聚糖 A、B、C、D 和 E，它们在正常小鼠中表现出降血糖作用。主要的聚糖天花粉聚糖 A 在四氧嘧啶诱导的高血糖小鼠中也表现出活性。
