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运动员血脂异常的诊断与治疗

Diagnosis and Treatment of Dyslipidaemias in Athletes.

作者信息

Christou Georgios A, Kouidi Evangelia J, Deligiannis Asterios P, Kiortsis Dimitrios N

机构信息

Laboratory of Physiology, Medical School, University of Ioannina, Ioannina, Greece.

Laboratory of Sports Medicine, Sports Medicine Division, Aristotle University of Thessaloniki, Thessaloniki, Greece.

出版信息

Curr Vasc Pharmacol. 2017;15(3):238-247. doi: 10.2174/1570161115666170127162526.

Abstract

The beneficial effects of chronic exercise training on lipoprotein metabolism include a considerable increase in serum high density lipoprotein-cholesterol and a reduction in serum triglyceride levels. These changes are mostly reported in athletes participating in dynamic sports, especially in the endurance ones. Diagnosis and treatment of dyslipidaemias in athletes should follow the main principles of management of dyslipidaemias for the general population, while specific considerations for athletes should be taken into account. Dyslipidaemias in athletes are usually characterized by a significant genetic predisposition. Clinicians who evaluate the lipoprotein profile of athletes should keep in mind the possibility of an illegal use of performance-enhancing drugs, which can influence lipoprotein metabolism. Lifestyle intervention should be the cornerstone of treatment of dyslipidaemias in athletes, but it should be tailored to the needs of individual athletic activity. Hypolipidaemic medications may not be well-tolerated by competitive athletes and should be reserved only for athletes with inadequate response to lifestyle measures. The treatment of dyslipidaemias in athletes should aim at reducing cardiovascular risk without compromising athletic performance.

摘要

长期运动训练对脂蛋白代谢的有益影响包括血清高密度脂蛋白胆固醇显著增加以及血清甘油三酯水平降低。这些变化大多在参与动态运动的运动员中报道,尤其是耐力项目运动员。运动员血脂异常的诊断和治疗应遵循一般人群血脂异常管理的主要原则,同时应考虑运动员的特殊情况。运动员的血脂异常通常具有显著的遗传易感性。评估运动员脂蛋白谱的临床医生应牢记运动员非法使用提高成绩药物的可能性,这可能会影响脂蛋白代谢。生活方式干预应是运动员血脂异常治疗的基石,但应根据个体运动活动的需求进行调整。降脂药物可能不为竞技运动员所耐受,应仅保留给对生活方式措施反应不足的运动员。运动员血脂异常的治疗应旨在降低心血管风险,同时不影响运动表现。

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