沃夫勒姆病中的躁狂：从床边到实验室
Mania in Wolfram's Disease: From Bedside to Bench.
作者信息
Chatterjee Seshadri Sekhar, Mitra Sayantanava, Pal Salil Kumar
机构信息
Department of Psychiatry, Medical College, Calcutta National Medical College, Kolkata, India.
Consultant Psychiatrist, Calcutta National Medical College, Kolkata, India.
出版信息
Clin Psychopharmacol Neurosci. 2017 Feb 28;15(1):70-72. doi: 10.9758/cpn.2017.15.1.70.
Abstract
Wolfram syndrome is a relatively unexplored entity in clinical psychiatry. Historically, the discovery of a specific gene had generated huge fanfare regarding specific genetic causations of psychiatric disorders. While the initial enthusiasm has faded now, association of Wolfram syndrome with psychiatric illnesses like schizophrenia, psychosis and suicidal behavior still remain important for understanding biological underpinnings of such disorders. We report a case of Wolfram syndrome presenting with multiple manic episodes, discuss possible genetic underpinnings for the affective symptoms and then discuss certain issues regarding management.
摘要
沃尔弗拉姆综合征在临床精神病学中是一个相对未被充分探索的领域。从历史上看，一个特定基因的发现曾引发了关于精神障碍特定遗传病因的巨大轰动。虽然最初的热情现已消退，但沃尔弗拉姆综合征与精神分裂症、精神病和自杀行为等精神疾病的关联，对于理解此类疾病的生物学基础仍然很重要。我们报告一例表现为多次躁狂发作的沃尔弗拉姆综合征病例，讨论情感症状可能的遗传基础，然后讨论一些管理方面的问题。
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Mania in Wolfram's Disease: From Bedside to Bench.沃夫勒姆病中的躁狂：从床边到实验室
Clin Psychopharmacol Neurosci. 2017 Feb 28;15(1):70-72. doi: 10.9758/cpn.2017.15.1.70.
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