Soltanipur Masood, Rohani Bastami Mohammadhosein, Shahshenas Sina, Ghorbanniadelavar Zahra, Barouh Alireza, Shadmand Alireza, Karimi Nemch Mohammadreza, Yarmohammadi Hossein, Siadat Seyed Davar, Jalali Nadoushan Mohammadreza
Quality of Life Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, Iran.
General Practitioner (GP), Avicenna Hospital, Tehran, Iran.
Indian J Otolaryngol Head Neck Surg. 2025 Jan;77(1):608-619. doi: 10.1007/s12070-024-05172-y. Epub 2024 Nov 1.
Nasal polyp (NP) is a pathological benign mass that affects the nasal cavity and paranasal sinuses. This lesion is occasionally associated with chronic rhinosinusitis (CRS), which is named chronic rhinosinusitis with nasal polyps (CRSwNP). Proliferating cell nuclear antigen (PCNA) indicates abnormal cell proliferation which may help assess the nasopharyngeal lesions and upper airway cancers. This study aimed to examine the PCNA expression in NP tissue. This study was conducted under the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines. A thorough search using relevant keywords was performed on the electronic database to identify studies examining the PCNA expression in NP. Meta-analysis on pooled single group proportion and means of PCNA expression was conducted by the metamean and metaprop functions in R software (version 4.4.0). Quality assessment was done according to the Joanna Briggs Institute (JBI) checklist. Ten articles were included in this study. The PCNA expression in NP was higher than in normal nasal mucosa (NNM), while its expression in NP was lower than in inverted papilloma (IP). The mean percentage of PCNA expression in NP was 15.73% (95%-CI[2.87-28.58]) with considerable heterogeneity ( = 97%[96-98%],-value < 0.01). Based on a cutoff staining (> 5%), 64% of NP samples were PCNA-positive (95%-CI[42-81%]) with high heterogeneity ( = 76%[47-89%], -value < 0.01). NP tissue has a relatively high expression of the PCNA oncoprotein based on the immunohistochemistry (IHC) staining. Although more than half of NP samples were positive for PCNA, still the mean expression of this marker in NP was lower than in IP tissue.
The online version contains supplementary material available at 10.1007/s12070-024-05172-y.
鼻息肉（NP）是一种影响鼻腔和鼻窦的病理性良性肿物。这种病变偶尔与慢性鼻窦炎（CRS）相关，后者被称为伴鼻息肉的慢性鼻窦炎（CRSwNP）。增殖细胞核抗原（PCNA）表明细胞异常增殖，这可能有助于评估鼻咽部病变和上呼吸道癌症。本研究旨在检测NP组织中PCNA的表达情况。本研究按照系统评价和Meta分析的首选报告项目（PRISMA）指南进行。在电子数据库中使用相关关键词进行全面检索，以识别检测NP中PCNA表达的研究。通过R软件（版本4.4.0）中的metamean和metaprop函数对PCNA表达的合并单组比例和均值进行Meta分析。根据乔安娜·布里格斯研究所（JBI）清单进行质量评估。本研究纳入了10篇文章。NP中PCNA的表达高于正常鼻黏膜（NNM），而其在NP中的表达低于内翻性乳头状瘤（IP）。NP中PCNA表达的平均百分比为15.73%（95%置信区间[2.87 - 28.58]），具有相当大的异质性（I² = 97%[96 - 98%]，P值<0.01）。基于截断染色（>5%），64%的NP样本PCNA呈阳性（95%置信区间[42 - 81%]），具有高度异质性（I² = 76%[47 - 89%]，P值<0.01）。基于免疫组织化学（IHC）染色，NP组织中PCNA癌蛋白表达相对较高。尽管超过一半的NP样本PCNA呈阳性，但该标志物在NP中的平均表达仍低于IP组织。
在线版本包含可在10.1007/s12070 - 024 - 05172 - y获取的补充材料。
