Kalem Muberra Namlı, Kalem Ziya, Akgun Nilufer, Bakırarar Batuhan
Department of Obstetrics and Gynecology, Faculty of Medicine, Turgut Ozal University, Ankara, Turkey.
Gurgan Clinic IVF and Women Health Center, Ankara, Turkey.
Arch Gynecol Obstet. 2017 Mar;295(3):785-793. doi: 10.1007/s00404-017-4288-x. Epub 2017 Jan 31.
To investigate the relationship between postmenopausal women's sclerostin levels and bone density and the factors that may affect this relationship.
135 postmenopausal patients' ages, BMIs, hormonal statuses, BMD values, and smoking, and consumption of coffee and dairy products were compared with their sclerostin levels.
No statistical relationship was found between sclerostin level and age in the group with osteoporosis (p = 0.204, r = -0.305). There was a positive, high-level relationship between sclerostin levels and BMI in the osteoporosis group and it was found to be statistically significant (p < 0.001, r = 0.786). No statistical relationship was found between sclerostin level and age in the non-osteoporosis group with (p = 0.496, r = -0.88). There was a positive, moderate relationship between sclerostin levels and BMI in the non-osteoporosis group and it was found to be statistically significant (p < 0.001, r = 0.505). No statistically significant relationship could be found between sclerostin levels and vitamin D (p = 0.723), PTH (p = 0.112), FSH (p = 0.795), E (p = 0.627), TSH (p = 0.517), T (p = 0.788), and T (p = 0.664) blood levels. No significant difference was found among the groups formed by smoking, consumption of coffee and milk, and dairy products, either (p = 0.405; p = 0.626; p = 0.234, respectively). It was monitored that sclerostin's negative effect observed on BMD scores was independent from age; however, it had a positive correlation with BMI.
As blood sclerostin levels increase, bone mineral density decreases. This negative effect of sclerostin on bone density increases as BMI increases, too. Effects of sclerostin levels on bone density are independent from age, and they are not affect by levels of vitamin D: PTH, FSH, E and thyroid hormones, and daily activities, such as smoking and consumption of coffee and milk and dairy products, either.
探讨绝经后女性硬化素水平与骨密度之间的关系以及可能影响这种关系的因素。
比较135例绝经后患者的年龄、体重指数、激素状态、骨密度值、吸烟情况以及咖啡和乳制品的摄入量与她们的硬化素水平。
骨质疏松组中，硬化素水平与年龄之间未发现统计学关系（p = 0.204，r = -0.305）。骨质疏松组中，硬化素水平与体重指数呈正相关且高度相关，差异有统计学意义（p < 0.001，r = 0.786）。非骨质疏松组中，硬化素水平与年龄之间未发现统计学关系（p = 0.496，r = -0.88）。非骨质疏松组中，硬化素水平与体重指数呈正相关且中度相关，差异有统计学意义（p < 0.001，r = 0.505）。硬化素水平与维生素D（p = 0.723）、甲状旁腺激素（p = 0.112）、促卵泡激素（p = 0.795）、雌二醇（p = 0.627）、促甲状腺激素（p = 0.517）、睾酮（p = 0.788）和三碘甲状腺原氨酸（p = 0.664）的血药浓度之间未发现显著统计学关系。吸烟、饮用咖啡和牛奶以及食用乳制品所形成的组间也未发现显著差异（p分别为0.405、0.626、0.234）。监测发现，硬化素对骨密度评分的负面影响与年龄无关；然而，它与体重指数呈正相关。
随着血硬化素水平升高，骨矿物质密度降低。硬化素对骨密度的这种负面影响也随着体重指数的增加而增加。硬化素水平对骨密度的影响与年龄无关，也不受维生素D、甲状旁腺激素、促卵泡激素、雌二醇和甲状腺激素水平以及吸烟、饮用咖啡和牛奶及食用乳制品等日常活动的影响。
