Are Chandrakanth, Ahmad Humera, Ravipati Advaitaa, Croo Darren, Clarey Dillon, Smith Lynette, Price Ray R, Butte Jean M, Gupta Sameer, Chaturvedi Arun, Chowdhury Sanjib
Division of Surgical Oncology, Department of Surgery, University of Nebraska Medical Center, Omaha, Nebraska.
Department of Surgery, Gundersen Medical Foundation, La Crosse, Wisconsin.
J Surg Oncol. 2017 Apr;115(5):580-590. doi: 10.1002/jso.24546. Epub 2017 Jan 30.
The aim of this study is to describe the trends and variations in the global burden of gallbladder cancer (GBC) with an emphasis on geographic variations and female gender.
Data (2012-2030) relating to GBC was extracted from GLOBOCAN 2012 database and analyzed.
The results of our study document a rising global burden of GBC with geographic and gender variations. The highest burden was noted in the WPRO region (based on WHO regions), Asia (based on continents) and India, Chile, and China (based on countries). The less developed regions of the world account for the majority of the global burden of GBC. The geographic variations are also present within individual countries such as in India and Chile. Females are afflicted at a much higher rate with GBC and this predilection is exaggerated in countries with higher incidence such as India and Chile. In females, people of certain ethnic groups and lower socio-economic standing are at a higher risk.
Our study demonstrates a rising global burden of GBC with some specific data on geographic and gender-based variations which can be used to develop strategies at the global as well as the high-risk individual country level.
本研究旨在描述胆囊癌（GBC）全球负担的趋势和变化，重点关注地理差异和女性情况。
从GLOBOCAN 2012数据库中提取并分析了与胆囊癌相关的数据（2012 - 2030年）。
我们的研究结果表明，胆囊癌的全球负担呈上升趋势，存在地理和性别差异。在西太平洋区域（基于世界卫生组织区域）、亚洲（基于各大洲）以及印度、智利和中国（基于国家）观察到最高负担。世界上较不发达地区占胆囊癌全球负担的大部分。地理差异在印度和智利等个别国家也存在。女性患胆囊癌的比例要高得多，在印度和智利等发病率较高的国家，这种倾向更为明显。在女性中，某些种族群体和社会经济地位较低的人风险更高。
我们的研究表明胆囊癌的全球负担在上升，并提供了一些关于地理和性别差异的具体数据，可用于在全球以及高风险的个别国家层面制定策略。
