Are Chandrakanth, Meyer Bria, Stack Apollo, Ahmad Humera, Smith Lynette, Qian Biyun, Song Tianqiang, Chowdhury Sanjib
Division of Surgical Oncology, Department of Surgery, University of Nebraska Medical Center, Omaha, Nebraska.
College of Medicine, University of Nebraska Medical Center, Omaha, Nebraska.
J Surg Oncol. 2017 Apr;115(5):591-602. doi: 10.1002/jso.24518. Epub 2017 Mar 26.
The aim of this study is to describe the influence of geography, socio-economic development, and demographic shift on the trends in global incidence, mortality, and prevalence of liver cancer (LC).
Data (2012-2030) relating to LC and demographic shifts based on WHO regions and HDI areas were extracted from GLOBOCAN 2012 and analyzed to evaluate trends in incidence, mortality, and prevalence.
The results of our study document a rising global burden of LC with the maximum impact in the WPRO region. We did not observe a definite association between LC and higher socio-economic status with the highest burden in the MHD region. For the MHD region, we noticed age reversal in burden from the younger age group currently to the older age group in the future (2030). Another finding is the high burden and early onset of disease in some low-income countries such as Mongolia, Lao PDR, and Vietnam.
The results of our study demonstrate a rising global burden of LC with some significant but uneven trends based on geography, age, and socio-economic status. This information can be used to shape policy and aid strategic targeting of resources to areas with the highest burden.
本研究旨在描述地理因素、社会经济发展及人口结构变化对全球肝癌（LC）发病率、死亡率及患病率趋势的影响。
从GLOBOCAN 2012中提取基于世界卫生组织区域和人类发展指数地区的与肝癌及人口结构变化相关的数据（2012 - 2030年），并进行分析以评估发病率、死亡率及患病率趋势。
我们的研究结果表明全球肝癌负担呈上升趋势，其中西太平洋区域受影响最大。我们未观察到肝癌与较高社会经济地位之间存在明确关联，中等人类发展指数区域负担最高。对于中等人类发展指数区域，我们注意到负担从当前的年轻年龄组向未来（2030年）的老年年龄组出现逆转。另一发现是一些低收入国家如蒙古、老挝和越南肝癌负担高且发病早。
我们的研究结果表明全球肝癌负担呈上升趋势，基于地理、年龄和社会经济地位存在一些显著但不均衡的趋势。这些信息可用于制定政策并帮助将资源战略靶向负担最高的地区。
